The present disclosure is based on the discovery that a clinical grade compound of Formula (I) potently blocks TGF-β activity and significantly reverse the activated phenotypes of myofibroblast in vitro. The compound of Formula (I) can be used in the treatment of fibrotic conditions in general, such as non-alcoholic steatohepatitis (NASH), cirrhosis, HBV infection, any liver disease, pulmonary fibrosis, interstitial lung disease, idiopathic pulmonary fibrosis (IPF), renal fibrosis, cardiac fibrosis, or any combination thereof.