A protective garment with a good antibacterial effect, comprising a top (1), trousers (2) arranged at the bottom of the top, a protective cap (5) sewn at the top of the top (1) and on the surface of a collar. A waterproof layer (6) is comprised inside the top. An antibacterial material (8) is added inside the protective garment to achieve an antibacterial effect. The antibacterial material (8) adopts an existing antibacterial fiber and is double-layered to enhance the antibacterial effect, prevent the growth of bacteria, and ensure the cleanliness of the protective garment. The waterproof layer (6) provided on the outer surface can effectively block moisture, and an inner sweat-absorbing and dehumidifying layer (9) is made of an existing moisture-absorbing and wicking fiber and effectively absorbs sweat produced on the body surface and improves comfort. Additionally, the protective garment solves the problem in which a protective garment has poor antibacterial performance resulting in bacteria attached to the surface thereof being brought into a sterile work environment, causing problems for experimental work.