- 专利标题： GENETIC ELEMENTS DRIVING CIRCULAR RNA TRANSLATION AND METHODS OF USE
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申请号： PCT/US2021/039127申请日： 2021-06-25
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公开(公告)号： WO2021263124A2公开(公告)日： 2021-12-30
- 发明人: CHANG, Howard Y. , CHEN, Chun-Kan
- 申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 申请人地址： Office of the General Counsel
- 专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人地址： Office of the General Counsel
- 代理机构： KARABINIS, Melissa E.
- 优先权： US63/043,964 2020-06-25
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; C12N15/117 ; C12N15/67
摘要：
Provided herein are recombinant circular RNA (circRNA) molecules comprising an internal ribosome entry site (IRES) operably linked to a protein-coding nucleic acid sequence. The IRES includes at least one RNA secondary structure element; and a sequence region that is complementary to an 18S ribosomal RNA (rRNA). Methods of producing a protein in a cell using the recombinant circRNA molecules are also provided.
