发明申请
- 专利标题： NOVEL AMIDE DERIVATIVES
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申请号： PCT/IB2021/058878申请日： 2021-09-29
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公开(公告)号： WO2022070048A1公开(公告)日： 2022-04-07
- 发明人: SHARMA, Rajiv , AGARWAL, Sameer
- 申请人： CADILA HEALTHCARE LIMITED
- 申请人地址： Zydus Corporate Park, Scheme No. 63, Survey No. 536, Khoraj (Gandhinagar), Nr. Vaishnodevi Circle, Sarkhej – Gandhinagar Highway,
- 专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人： CADILA HEALTHCARE LIMITED
- 当前专利权人地址： Zydus Corporate Park, Scheme No. 63, Survey No. 536, Khoraj (Gandhinagar), Nr. Vaishnodevi Circle, Sarkhej – Gandhinagar Highway,
- 代理机构： ELANGBAM, Nanda et al.
- 优先权： IN202021042238 2020-09-29
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; A61P11/00
摘要：
The present invention relates to novel compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as the compounds of the invention belong to the family of papain-like protease (PLpro) modulators. The present invention thus relates to novel papain-like protease (PLpro) modulators and their use in the treatment of diseases or conditions in which SARS-CoV, SARS-CoV2 is implicated like severe acute respiratory syndrome (SARS), Middle east respiratory syndrome (MERS), Spanish flu, COVID19 (Coronavirus disease 2019), hepatitis C virus, chikungunya virus, influenza A virus, herpes simplex virus type 1 and Japanese encephalitis virus. Formula (I)
IPC分类:
