Provided herein are compositions, methods and kits for effectively preventing, treating, reducing, mitigating, or controlling female sexual interest and arousal disorder (FSIAD), wherein the method comprises administering to a subject in need thereof (i) a non-steroidal anti-androgen drug having minimal blood-brain-barrier penetration in a dosage that completely or partially blocks peripheral androgen receptors; and (ii) a supra-physiological dose of an anabolic androgenic steroid (AAS), a pro-drug, precursor or pro-hormone of an AAS, or a selective androgen receptor modulator (SARM).