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发明申请
WO2022126426A1 一种负载药物、活性因子、细胞的可控梯度支架及其3D打印方法和专用多喷头3D打印机 审中-公开

一种负载药物、活性因子、细胞的可控梯度支架及其3D打印方法和专用多喷头3D打印机
摘要：
涉及生物组织和器官3D打印的技术领域，尤其是涉及一种负载药物、活性因子、细胞的可控梯度支架及其3D打印方法和多喷头3D打印机。可控梯度支架一步交替打印成型；一体化梯度支架至少包括有两种材料：第一材料和第二材料；第一材料负载有负载药物、活性因子或细胞的一种或多种；第二材料负载有负载药物、活性因子或细胞的一种或多种；第一材料和第二材料分别交替打印后构建成一体化梯度支架。构建的负载药物、活性因子、细胞一体化梯度支架不存在双层梯度界面不牢固，易脱落的问题。使用多喷头交替打印的方式构建三维细胞的一体化梯度支架，为实现生物体复杂组织器官的构建提供了基础。
摘要（英）：

The present disclosure relates to the technical field of 3D printing for biological tissues and organs, and in particular to a controllable gradient scaffold for loading a drug, an active factor and a cell, a 3D printing method therefor, and a multi-nozzle 3D printer. The controllable gradient scaffold is formed in one step by alternating printing. The integrated gradient scaffold at least comprises two materials, namely a first material and a second material. The first material is loaded with one or more of the load drug, the active factor or the cell, and the second material is loaded with one or more of the load drug, the active factor or the cell. After the first material and the second material are respectively alternatingly printed, the integrated gradient scaffold is constructed. The constructed integrated gradient scaffold for loading the drug, the active factor and the cell is free from the problem that a double-layer gradient interface is loose and prone to falling off. The integrated gradient scaffold for three-dimensional cells is constructed by means of multi-nozzle alternating printing, thereby laying the foundation for constructing complex tissues and organs of organisms.

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