Methods, apparatus, systems, and articles of manufacture are disclosed to optimize resources in edge networks. An example apparatus includes agent managing circuitry to invoke an exploration agent to identify platform resource devices, select a first one of the identified platform resource devices, and generate first optimization metrics for the workload corresponding to the first one of the identified platform resource devices, the first optimization metrics corresponding to a first path. The example agent is to further select a second one of the identified platform resource devices, generate second optimization metrics for the workload corresponding to the second one of the identified platform resource devices, the second optimization metrics corresponding to a second path. The example apparatus also includes benchmark managing circuitry to embed second semantic information to the workload, the second semantic information including optimized graph information and platform structure information corresponding to the second one of the identified platform resource devices, and reconfiguration managing circuitry to select the first path or the second path during runtime based on (a) service level agreement (SLA) information and (b) utilization information corresponding to the first and second identified platform resource devices.