Invention Application
- Patent Title: RIFAMYCIN ANALOGS
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Application No.: PCT/US2022/012980Application Date: 2022-01-19
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Publication No.: WO2022159491A1Publication Date: 2022-07-28
- Inventor: GARCIA, George , SHOWALTER, Hollis , RAJESWARAN, Walajapet , LEE, Pil , FRANZBLAU, Scott , MURAKAMI, Katsuhiko
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE PENN STATE RESEARCH FOUNDATION
- Applicant Address: 1600 Huron Parkway; 506 S. Wright Street; 304 Old Main
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS,THE PENN STATE RESEARCH FOUNDATION
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS,THE PENN STATE RESEARCH FOUNDATION
- Current Assignee Address: 1600 Huron Parkway; 506 S. Wright Street; 304 Old Main
- Agency: REYNOLDS, Anne M.
- Priority: US63/139,119 2021-01-19
- Main IPC: A61K31/5386
- IPC: A61K31/5386 ; A61P31/06 ; C07D498/18
Abstract:
Provided herein are compounds that are potent inhibitors of the Mycobacterium tuberculosis (MTB) RNA polymerase (RNAP), which exhibit significantly reduced activation of the human pregnane X receptor (hPXR), resulting in dramatically reduced induction of hepatic cytochromes P450 2C9 and 3A4 (CYP2C9, CYP3A4), as well as a number of Phase II metabolism enzymes. Also provided herein are pharmaceutical compositions comprising the compounds, and methods of treating tuberculosis using the compounds.
Information query
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