Invention Application
- Patent Title: GUIDE RNAS AND USES THEREOF
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Application No.: PCT/EP2022/053040Application Date: 2022-02-08
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Publication No.: WO2022167694A1Publication Date: 2022-08-11
- Inventor: BONINI, Maria Chiara , CIANCIOTTI, Beatrice Claudia , RUGGIERI, Eliana , POTENZA, Alessia
- Applicant: OSPEDALE SAN RAFFAELE S.R.L. , FONDAZIONE CENTRO SAN RAFFAELE
- Applicant Address: Via Olgettina, 60; Via Olgettina, 60
- Assignee: OSPEDALE SAN RAFFAELE S.R.L.,FONDAZIONE CENTRO SAN RAFFAELE
- Current Assignee: OSPEDALE SAN RAFFAELE S.R.L.,FONDAZIONE CENTRO SAN RAFFAELE
- Current Assignee Address: Via Olgettina, 60; Via Olgettina, 60
- Agency: TURRI, Elisa et al.
- Priority: EP21155865.5 2021-02-08
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K39/00 ; A61P35/00
Abstract:
The present invention is related to an isolated guide ribonucleic acid (gRNA) comprising a guide sequence targeting an inhibitory receptor (IR), a TCR α (TRAC) constant region or a β chain (TRBC1/2) constant region target sequence, wherein said guide sequence is selected from the group consisting of SEQ ID NOs:1-27, 122-126 and combinations thereof.
Information query
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