The present disclosure relates an advanced microfluidic system for the validation and study of nanomaterials, drugs, or mixtures thereof, intended to be used in biomedical and/or pharmaceutic applications. It is disclosed a device for the production of an organoid cell culture or cultures, comprising: a base layer for support; a transducer layer arranged on the base layer; and an intermediate layer, arranged on the transducer layer, comprising a plurality of openings to form cavities for organoid cell growth and a microchannel network for fluid flow; wherein the transducer layer comprises a heating device and at least a plurality of sensor in each cavity for cell parameter control and growth; wherein each sensor is located for measuring an organoid cell growth parameter in the interior of each cavity; wherein the heating device is located in the interior of each cavity; wherein the heating device and the plurality of sensors are in direct contact with the organoid cell culture or cultures; wherein the plurality of sensors is selected from temperature sensor, pH sensor, heaters or combinations thereof.