The present invention relates to a biomarker composition for differential diagnosis of pancreas neuroendocrine tumors and a method for providing information required in the differential diagnosis of pancreas neuroendocrine tumors by using same. Since differential diagnosis of pancreas neuroendocrine tumors is carried out through a convenient and simple method in which the expression levels of proteins such as CD163, ACTR3 and S100A9 or genes encoding same are measured in a biological sample of an individual suspected to have pancreas neuroendocrine tumors and are compared with the expression levels of a patient with pancreatic ductal adenocarcinoma so that an appropriate treatment method can be applied at an early stage, the present invention can be effectively used in the diagnosis and treatment of pancreas neuroendocrine tumors.