The present invention relates to an office protection system for blocking respiratory viruses, and provides users with individual office spaces so that the users can work while sitting in an inner space. The inner space of a booth is maintained at positive pressure by spraying air downward from the top inside the booth via an air supply unit that supplies purified air, and thus it is possible to prevent outside polluted air from entering the inner space of the booth. In addition, an accommodation unit is provided on one side of the booth so that the transfer of various items including approval documents can occur non-face-to-face, and thus it is possible to prevent group infection by minimizing contact between workers.