The invention is related to a method for providing guidance data (30, 41) for positioning a region of interest (20, 31, 41, 56) of a subject (54), an X-ray source (52), and an X-ray detector (21, 34, 53). The method comprises: obtaining, by a processor (11), current positioning data of at least one palpable bony landmark (23, 33) derived from a palpation; obtaining current positioning data of the X-ray source (52) and of the X-ray detector (21, 34, 53) (S20); determining guidance data (30, 41) for positioning the region of interest (20, 31, 41, 56), the X-ray source (52) and the X-ray detector (21, 34, 53) and providing, by the processor (11), the guidance data (30, 41) (S40).