Invention Application
- Patent Title: TRANSMEMBRANE PEPTIDIC ANTAGONISTS OF PLEXIN-A1 AND THEIR THERAPEUTIC USES
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Application No.: PCT/EP2022/074907Application Date: 2022-09-07
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Publication No.: WO2023036842A1Publication Date: 2023-03-16
- Inventor: BAGNARD, Dominique , BINAME, Fabien
- Applicant: UNIVERSITE DE STRASBOURG , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Applicant Address: 4 rue Blaise Pascal; 101 rue de Tolbiac
- Assignee: UNIVERSITE DE STRASBOURG,INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee: UNIVERSITE DE STRASBOURG,INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
- Current Assignee Address: 4 rue Blaise Pascal; 101 rue de Tolbiac
- Agency: CABINET BECKER ET ASSOCIES
- Priority: EP21306229.2 2021-09-08
- Main IPC: A61K38/03
- IPC: A61K38/03 ; A61K38/04 ; A61P25/00 ; A61P35/00
Abstract:
The present application relates to peptides derived from the transmembrane domain of Plexin-A1 that inhibits Neuropilin-1/Plexin-A1 heterodimerization. These peptides neutralize the inhibitory effect of Sema3A on cell migration and angiogenesis, and may be useful for the treatment of diseases associated with Sema3A and/or Neuropilin-1/Plexin-A1 activity, such as demyelinating diseases and diseases associated with abnormal angiogenesis such as cancer.
Information query
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