Invention Application
- Patent Title: GPX4 INHIBITORS AND USES THEREOF
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Application No.: PCT/US2022/076179Application Date: 2022-09-09
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Publication No.: WO2023039510A1Publication Date: 2023-03-16
- Inventor: STOCKWELL, Brent R. , LIU, Hengrui , FOROUHAR, Farhad , XIA, Xin , LIN, Annie , WANG, Qian
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: 412 Low Memorial Library
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: 412 Low Memorial Library
- Agency: YANG, Ke
- Priority: US63/242,829 2021-09-10
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/08
Abstract:
The present disclosure provides, inter alia, compounds to modulate GPX4 activity. Also provided are pharmaceutical compositions containing same compounds. Further provided are methods for treating or ameliorating the effects of a cancer in a subject, methods of modulating GPX activity in a subject, methods of inducing ferroptosis in a cell, and methods for treating or ameliorating the effects of a cancer in a subject using the compounds or composition in combination with other therapeutic agents.
Information query
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