The present invention relates to a pressurization and oxygen supplementation modular residential complex in a high-altitude area. The complex uses a modular design and comprises module units, i.e., several standard compartments, a connecting node compartment, a connecting walkway compartment, a transition compartment, an equipment compartment, a sewage collecting compartment and a large-span space, wherein each module unit can be subjected to free assembly and any functional expansion in a plane direction and a vertical direction; the standard compartments are used for meeting a plurality of functional scenario requirements; the connecting node compartment and the connecting walkway compartment are used for spatial communication and personnel traffic between the standard compartments, between the standard compartment and the transition compartment and between the standard compartment and the large-span space; the transition compartment is used for indoor and outdoor pressure transition and personnel in-out of the complex; an intelligent pressurization and oxygen supplementation system is arranged in the equipment compartment; the sewage collecting compartment is used for collecting and treating sewage in the complex; and the large-span space is used for multicrowd large meetings, large gatherings and sports. The present invention meets the design requirements of a larger spatial scale, a higher pressurization capability, more residential functions, and lower cost operation.