- 专利标题： SCO-SPONDIN-DERIVED POLYPEPTIDES FOR ENHANCING SYNAPTIC TRANSMISSION
-
申请号： PCT/EP2022/066615申请日： 2022-06-17
-
公开(公告)号： WO2023280550A1公开(公告)日： 2023-01-12
- 发明人: LEMARCHANT, Sighild, Brunhilde, Adeline , GODFRIN, Yann , SOURIOUX, Mélissa, Christine
- 申请人： AXOLTIS PHARMA
- 申请人地址： 15-17 rue du Pré de la Reine
- 专利权人： AXOLTIS PHARMA
- 当前专利权人： AXOLTIS PHARMA
- 当前专利权人地址： 15-17 rue du Pré de la Reine
- 代理机构： COLOMBET, Alain et al.
- 优先权： EP21305959.5 2021-07-09
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61P25/00 ; A61P25/18 ; A61P25/30 ; A61K38/1709
摘要：
The invention relates to polypeptides derived from SCO-spondin for increasing or enhancing the basal excitatory synaptic transmission, notably glutamatergic neurotransmission. More particularly the invention relates to said polypeptides for increasing or enhancing glutamatergic neurotransmission in diseases or conditions comprising psychiatric disorders; drug addiction; viral infection (such as coronaviruses, e.g. SARS CoV2) related neurological symptoms; NMDA receptor (NMDAr) and/or AMPA receptor (AMPAr) deficiency related disease, notably anti-NMDAr encephalitis; vegetative state, and hypoxic brain injury. The present invention also relates to methods of treatment.
IPC分类:
