公开(公告)号：EP1027889B8

公开(公告)日：2006-07-05

申请号：EP00250117.9

申请日：1992-05-14

申请人： NeuroBiotec GmbH

发明人： Riedl, Jutta, Dr. ,  Günther, Clemens, Dr. ,  Lipp, Ralph, Dr.

IPC分类号： A61K9/70 ,  A61K31/48

CPC分类号： A61K9/7061 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/48

公开(公告)号：EP1027889B1

公开(公告)日：2005-12-07

申请号：EP00250117.9

申请日：1992-05-14

申请人： NeuroBiotec GmbH

发明人： Riedl, Jutta, Dr. ,  Günther, Clemens, Dr. ,  Lipp, Ralph, Dr.

IPC分类号： A61K9/70 ,  A61K31/48

CPC分类号： A61K9/7061 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/48

公开(公告)号：EP1311249A1

公开(公告)日：2003-05-21

申请号：EP01978306.7

申请日：2001-08-24

申请人： NeuroBiotec GmbH

发明人： WINDT-HANKE, Fred ,  GÜNTHER, Clemens ,  HOROWSKI, Reinhard ,  TACK, Johannes

IPC分类号： A61K9/70 ,  A61K31/48 ,  A61P5/08 ,  A61P5/24

CPC分类号： A61K9/7061 ,  A61K31/48

摘要： The invention relates to a use of a transdermal therapeutic system (TTS) for producing an agent for obtaining and maintaining the circadian rhythm under dopamine therapy. Said system comprises a pharmaceutical layer containing at least one matrix having an active ingredient; and/or an active ingredient reservoir; a diffusion barrier which is permeable to active ingredients and which is arranged on the skin side of the active ingredient reservoir; and an ergoline derivative or salt thereof having a physiologically compatible acid, as an active ingredient.

公开(公告)号：EP1303278A1

公开(公告)日：2003-04-23

申请号：EP01976150.1

申请日：2001-08-24

申请人： NeuroBiotec GmbH

发明人： HOROWSKI, Reinhard ,  TACK, Johannes

IPC分类号： A61K31/48 ,  A61P25/14 ,  A61P25/16 ,  A61K31/45 ,  A61K31/13 ,  A61K9/00 ,  A61K9/20 ,  A61K9/70

CPC分类号： A61K9/7061 ,  A61K31/48

摘要： The invention relates to the use of a dopamine agonist in the form of an agent, comprising at least two physically separate compositions, of which one is a transdermal therapeutic system (TTS), containing the dopaminergic agent and one or several other compositions containing the same dopaminergic agent and suitable for oral and/or parenteral administration. Said compositions are suitable for the individually dosed and controlled treatment of dopaminergically treatable diseases with the following elements: a) the TTS is continuously applied, b) within the duration of application in a) the composition for oral or parenteral dosage is administered.

公开(公告)号：EP1660054A1

公开(公告)日：2006-05-31

申请号：EP04735452.7

申请日：2004-05-30

申请人： NeuroBiotec GmbH

发明人： HOROWSKI, Reinhard ,  TACK, Johannes ,  BOSTEDT, Katalin Tisa ,  SCHENK, Dirk

IPC分类号： A61K9/70

CPC分类号： A61K9/7061 ,  A61K31/48 ,  A61K47/10

摘要： The invention relates to a transdermal, therapeutic system containing an ergolin compound, preferably lisuride, in which the ergolin compound is stabilised. The oxidation-sensitive ergolin compound is stabilised by a combination of at least one liposoluble, free-radical scavenging anti-oxidant, preferably di-tert.-butyl methyl phenol, di-tert.-butyl methoxyphenol, tocopherol or ubiquinone and a basic polymer.

公开(公告)号：EP0538433B1

公开(公告)日：2004-04-21

申请号：EP92909703.8

申请日：1992-05-14

申请人： NeuroBiotec GmbH

发明人： RIEDL, Jutta ,  GÜNTHER, Clemens ,  LIPP, Ralph

IPC分类号： A61K31/48 ,  A61K9/70

CPC分类号： A61K9/7061 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/48

公开(公告)号：EP1483264B1

公开(公告)日：2006-12-27

申请号：EP02798301.4

申请日：2002-12-21

申请人： NeuroBiotec GmbH

发明人： FLIEGER, Miroslav ,  PERTZ, Heinz ,  KRANDA, Karel ,  CVAK, Jan ,  GLUSA, Erika ,  JÄHNICHEN, Sven

IPC分类号： C07D457/12 ,  A61K31/48 ,  A61P43/00 ,  C07D457/02 ,  C07D457/04 ,  C07D519/02

CPC分类号： C07D519/02 ,  C07D457/04 ,  C07D457/12

摘要： The invention relates to 1-allyl ergot alkaloids and derivatives thereof, comprising characteristics that are selectively antagonistic towards 5-HT2-receptors, for preventing and alleviating among others, migraine headaches, Parkinson's disease and disorders of thrombocyte function.

公开(公告)号：EP1511486A1

公开(公告)日：2005-03-09

申请号：EP03738032.6

申请日：2003-06-13

申请人： NeuroBiotec GmbH

发明人： KRANDA, Karel ,  HOROWSKI, Reinhard ,  SONKA, Karel ,  TACK, Johannes

IPC分类号： A61K31/48 ,  A61P25/14

CPC分类号： A61K31/48

摘要： Disclosed is the oral use of dopamine partial agonists and the physiologically acceptable salts thereof in order to create a pharmaceutical preparation for treating the restless legs syndrome, which effectively controls the symptoms while having a significantly smaller undesired effect of a medicament than medicaments known in prior art.

公开(公告)号：EP1483264A2

公开(公告)日：2004-12-08

申请号：EP02798301.4

申请日：2002-12-21

申请人： NeuroBiotec GmbH

发明人： FLIEGER, Miroslav ,  PERTZ, Heinz ,  KRANDA, Karel ,  CVAK, Jan ,  GLUSA, Erika

IPC分类号： C07D457/12 ,  A61K31/48 ,  A61P43/00 ,  C07D457/02 ,  C07D457/04 ,  C07D519/02

CPC分类号： C07D519/02 ,  C07D457/04 ,  C07D457/12

摘要： The invention relates to 1-allyl ergot alkaloids and derivatives thereof, comprising characteristics that are selectively antagonistic towards 5-HT2-receptors, for preventing and alleviating among others, migraine headaches, Parkinson's disease and disorders of thrombocyte function.

公开(公告)号：EP1311248A1

公开(公告)日：2003-05-21

申请号：EP01978305.9

申请日：2001-08-24

申请人： NeuroBiotec GmbH

发明人： HOROWSKI, Reinhard ,  TACK, Johannes ,  ENGFER, Adalbert

IPC分类号： A61K9/70 ,  A61K31/48 ,  A61P25/14 ,  A61P5/08 ,  A61P5/24

CPC分类号： A61K9/7061 ,  A61K31/48

摘要： The invention relates to the use of a transdermal therapeutic system (TTS) comprising a medicinal layer, which contains at least one matrix comprising an active ingredient and /or an active ingredient reservoir and a diffusion barrier situated on the skin side of the active ingredient reservoir and permeable to active ingredients, in addition to, an ergoline-derivative or physiologically compatible salt with an acid thereof, as an active ingredient, for producing a means for treating the restless-legs-syndrome.