公开(公告)号：EP1192139B1

公开(公告)日：2012-04-18

申请号：EP00942823.6

申请日：2000-06-15

申请人： ABBOTT LABORATORIES

发明人： ALLEN, Michael, S. ,  PREMCHANDRAN, Ramiya, H. ,  CHANG, Sou-Jen ,  CONDON, Stephen ,  DEMATTEI, John, J. ,  KING, Steven, A. ,  KOLACZKOWSKI, Lawrence ,  MANNA, Sukumar ,  NICHOLS, Paul J. ,  PATEL, Hemant, H. ,  PATEL, Subhash, R. ,  PLATA, Daniel, J. ,  STONER, Eric, J. ,  TIEN, Jien-Heh, J. ,  WITTENBERGER, Steven, J.

IPC分类号： C07D215/14 ,  C07C69/96 ,  C07C68/06 ,  C07C271/12 ,  C07C269/06 ,  C07C43/303 ,  C07C33/03 ,  C07C47/22 ,  C07C57/04

CPC分类号： C07D215/14 ,  C07C68/06 ,  C07C69/96

摘要： The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.