公开(公告)号：EP3409669B1

公开(公告)日：2020-10-07

申请号：EP18182201.6

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-sheng ,  GONG, Yongjin ,  LI, Feng ,  BENCIVENGA, Nicholas, E. ,  DALGARNO, David, C. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  THOMAS, Ranny, M. ,  ZHU, Xiaotian ,  WEST, Angela, V. ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04 ,  C07D401/04

公开(公告)号：EP3143015B1

公开(公告)日：2019-02-20

申请号：EP15792086.9

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-Sheng ,  LI, Feng ,  DALGARNO, David, C. ,  GONG, Yongjin ,  ISHCHENKO, Alexey, V. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  WEST, Angela, V. ,  XU, Yongjin ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun ,  ZHU, Xiaotian

IPC分类号： C07D403/14 ,  C07D473/16 ,  A61K31/506 ,  A61K31/436 ,  A61P35/00

公开(公告)号：EP3157916B1

公开(公告)日：2018-12-12

申请号：EP15810340.8

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-sheng ,  GONG, Yongjin ,  LI, Feng ,  BENCIVENGA, Nicholas, E. ,  DALGARNO, David, C. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  THOMAS, Ranny, M. ,  ZHU, Xiaotian ,  WEST, Angela, V. ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07F9/65583

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

公开(公告)号：EP3778584A1

公开(公告)日：2021-02-17

申请号：EP20178478.2

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-sheng ,  GONG, Yongjin ,  LI, Feng ,  BENCIVENGA, Nicholas, E. ,  DALGARNO, David, C. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  THOMAS, Ranny, M. ,  ZHU, Xiaotian ,  WEST, Angela, V. ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D471/04

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.

公开(公告)号：EP3157916A1

公开(公告)日：2017-04-26

申请号：EP15810340.8

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-sheng ,  GONG, Yongjin ,  LI, Feng ,  BENCIVENGA, Nicholas, E. ,  DALGARNO, David, C. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  THOMAS, Ranny, M. ,  ZHU, Xiaotian ,  WEST, Angela, V. ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun

IPC分类号： C07D403/14 ,  C07D473/16

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07F9/65583

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

摘要翻译： 本文描述了调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及​​化合物，药物组合物和治疗与激酶活性相关的疾病和病症的方法，包括突变型EGFR和突变型HER2活性。

公开(公告)号：EP3409669A1

公开(公告)日：2018-12-05

申请号：EP18182201.6

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-sheng ,  GONG, Yongjin ,  LI, Feng ,  BENCIVENGA, Nicholas, E. ,  DALGARNO, David, C. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  THOMAS, Ranny, M. ,  ZHU, Xiaotian ,  WEST, Angela, V. ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04 ,  C07D401/04

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

公开(公告)号：EP3143015A1

公开(公告)日：2017-03-22

申请号：EP15792086.9

申请日：2015-05-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： HUANG, Wei-Sheng ,  LI, Feng ,  DALGARNO, David, C. ,  GONG, Yongjin ,  ISHCHENKO, Alexey, V. ,  KOHLMANN, Anna ,  SHAKESPEARE, William, C. ,  WEST, Angela, V. ,  XU, Yongjin ,  YOUNGSAYE, Willmen ,  ZHANG, Yun ,  ZHOU, Tianjun ,  ZHU, Xiaotian

IPC分类号： C07D403/14 ,  C07D473/16

CPC分类号： C07F9/6561 ,  C07D471/06 ,  C07D487/06 ,  C07D498/06

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

摘要翻译： 本文描述了调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及​​化合物，药物组合物和治疗与激酶活性相关的疾病和病症（包括突变型EGFR和突变型HER2活性）的方法。