公开(公告)号：EP3006443A4

公开(公告)日：2016-12-21

申请号：EP14807340

申请日：2014-06-06

申请人： ASTELLAS PHARMA INC

发明人： ISHIHARA TSUKASA ,  IKEGAI KAZUHIRO ,  KURIWAKI IKUMI ,  HISAMICHI HIROYUKI ,  TAKESHITA NOBUAKI ,  TAKEZAWA RYUICHI

IPC分类号： C07D409/10 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/5377 ,  A61K31/551 ,  A61P19/02 ,  A61P21/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D413/10

CPC分类号： A61K31/5377 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/551 ,  C07D409/10 ,  C07D413/10

摘要： [Problem] A compound which is useful as an IK1 channel activator is provided. [Means for Solution] As a result of studies on the IK1 channel activator, the present inventors have found that a benzothiophene compound shows effectiveness on visceral pain, inflammatory pain, osteoarthritis pain, neuropathic pain, or fibromyalgia, thereby completing the invention. A compound of the invention has an IK1 channel activation effect, and can also be used as an agent for preventing and/or treating visceral pain, inflammatory pain, osteoarthritis pain, neuropathic pain, or fibromyalgia. In addition, the IK1 channel activator can be used as an agent for preventing and/or treating inflammatory pain, osteoarthritis pain, neuropathic pain, and fibromyalgia.