公开(公告)号：EP2220078A2

公开(公告)日：2010-08-25

申请号：EP08845711.4

申请日：2008-10-28

申请人： Amgen, Inc

发明人： HARMANGE, Jean-christophe ,  MARTIN, Matthew W. ,  TEFFERA, Yohannes ,  SUBRAMANIAN, Raju ,  WHITE, Ryan ,  ZANON, Roger ,  LARROW, Jay ,  PAYACK, Joseph F. ,  DILMEGHANI SERAN, Mina

IPC分类号： C07D413/14 ,  A61K31/536 ,  A61P35/00

CPC分类号： C07D413/14

摘要： Selected benzomorpholine compounds are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2220078B1

公开(公告)日：2013-05-22

申请号：EP08845711.4

申请日：2008-10-28

申请人： Amgen, Inc

发明人： HARMANGE, Jean-christophe ,  MARTIN, Matthew W. ,  TEFFERA, Yohannes ,  SUBRAMANIAN, Raju ,  WHITE, Ryan ,  ZANON, Roger ,  LARROW, Jay ,  PAYACK, Joseph F. ,  DILMEGHANI SERAN, Mina

IPC分类号： C07D413/14 ,  A61K31/536 ,  A61P35/00

CPC分类号： C07D413/14