公开(公告)号：EP2099756A1

公开(公告)日：2009-09-16

申请号：EP07851012.0

申请日：2007-12-14

申请人： Astellas Pharma Inc.

发明人： INOUE, Yoshikazu ,  EIKYU, Yoshiteru ,  SHIRAI, Fumiyuki

IPC分类号： C07D213/74 ,  C07D241/20 ,  A61K31/44 ,  A61K31/4965

CPC分类号： C07D213/74 ,  C07D241/20 ,  C07D405/12

摘要： A compound having the following formula (I) : wherein - R1 is hydrogen, optionally substituted lower alkyl, cyclo (lower) alkyl, cyclo (higher) alkyl, optionally substituted aryl, optionally substituted heterocyclyl, or aryl-fused cyclo (lower) alkyl, R2 is hydrogen or halogen, Z is CH or N, X is formula (II) R3 is lower alkyl which may be substituted with -OH or optionally substituted aryl, or lower alkanoyl, R4 is hydrogen or lower alkyl, Y is optionally substituted lower alkylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.

摘要翻译： 具有下式（I）的化合物：其中-R 1是氢，任选取代的低级烷基，环（低级）烷基，环（高级）烷基，任选取代的芳基，任选取代的杂环基或芳基稠合的环（低级） ，R2是氢或卤素，Z是CH或N，X是式（II）R3是可以被-OH取代的低级烷基或任选取代的芳基或低级烷酰基，R4是氢或低级烷基，Y是任选取代的 低级亚烷基或其盐。 该化合物可用作组蛋白脱乙酰酶抑制剂。