公开(公告)号：EP3223855A1

公开(公告)日：2017-10-04

申请号：EP15804919.7

申请日：2015-11-26

申请人： Aston University

发明人： RATHBONE, Daniel Lee ,  WORTHINGTON, Tony ,  AL-MALAIKA, Sahar ,  HIRD, Matthew Justin ,  QUAYLE, Alexandria Rose

IPC分类号： A61K47/50 ,  A61P31/04

CPC分类号： C07J43/003 ,  A61K31/575 ,  A61K31/58 ,  A61K45/06 ,  A61K47/554 ,  C07J9/005 ,  C07J41/0061 ,  C08F293/005

摘要： The invention relates to compounds, compositions and polymers comprising a first component adapted to promote germination of Clostridium difficile (C.diff) and a second component which acts as an antimicrobial agent. Said compounds, compositions and polymers are useful for destroying C.diff where conventional antimicrobial agents are unsuccessful. The compositions can be formulated as coating or materials which actively destroy C.diff which come into contact with it. The germination promotion is induced by bile salts. The invention also relates to the use of such materials as a treatment for C.diff associated diseases and toxic megacolon.

摘要翻译： 本发明涉及包含适于促进艰难梭菌（C. diff）发芽的第一组分和作为抗微生物剂的第二组分的化合物，组合物和聚合物。 所述化合物，组合物和聚合物可用于破坏常规抗微生物剂不成功的C.diff。 该组合物可以配制成活性地破坏与其接触的C.diff的涂层或材料。 发芽促进是由胆盐引起的。 本发明还涉及这种材料作为治疗C.diff相关疾病和有毒巨结肠的用途。

公开(公告)号：EP2528952B1

公开(公告)日：2016-03-30

申请号：EP11704084.0

申请日：2011-01-28

申请人： Aston University

发明人： AL-MALAIKA, Sahar ,  LEWUCHA, Cezary

IPC分类号： C08F8/00 ,  C08F255/00 ,  C08F285/00 ,  C08L51/00

CPC分类号： C08F255/02 ,  C08F8/00 ,  C08F285/00 ,  C08K5/1345 ,  C08K5/1545 ,  C08K5/3435 ,  F16L9/127 ,  F16L9/147 ,  Y10T428/1352 ,  Y10T428/139 ,  C08F110/02 ,  C08F220/30

公开(公告)号：EP2528952A1

公开(公告)日：2012-12-05

申请号：EP11704084.0

申请日：2011-01-28

申请人： Aston University

发明人： AL-MALAIKA, Sahar ,  LEWUCHA, Cezary

IPC分类号： C08F8/00 ,  C08F255/00 ,  C08F285/00 ,  C08L51/00

CPC分类号： C08F255/02 ,  C08F8/00 ,  C08F285/00 ,  C08K5/1345 ,  C08K5/1545 ,  C08K5/3435 ,  F16L9/127 ,  F16L9/147 ,  Y10T428/1352 ,  Y10T428/139 ,  C08F110/02 ,  C08F220/30

摘要： The present invention is concerned with the process for preparing a cross-linked stabilised polymer composition using at least one graftable polymer stabiliser, and the subsequent use of that composition for forming pipes, for example PEX pipes. The graftable stabiliser becomes anchored to the polymer such that stabiliser activity is retained in the cross-linked product. Cross-linking can be achieved by conventional processes such as PEXa, PEXb and PEXc. Embodiments demonstrate excellent levels of antioxidant retention (as measured by oxidative induction retention after exhaustive solvent extraction) and the cross-linked product are suitable for portable water applications, including hot water applications.