IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF
    1.
    发明公开
    IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF 审中-公开
    免疫调节剂EIGENSCHAFTEN VON MULTIPOTENTEN ADULTENVORLÄUFERZELLENUND IHRE VERWENDUNG

    公开(公告)号:EP1951294A1

    公开(公告)日:2008-08-06

    申请号:EP06837336.4

    申请日:2006-11-09

    IPC分类号: A61K39/00 A61K35/28 A61P37/06

    摘要: Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

    摘要翻译: 描述了不是胚胎干细胞,而不是胚胎生殖细胞,而不是生殖细胞的分离的细胞。 细胞可以分化为至少两种内胚层,外胚层和中胚层谱系中的至少一种细胞类型。 细胞不会引起有害的免疫反应。 细胞可以调节免疫反应。 作为示例,细胞可以抑制由同种异体细胞,组织和器官产生的宿主中的免疫应答。 描述了使用细胞本身或辅助地治疗受试者的方法。 例如,细胞可以辅助地用于移植治疗中的免疫抑制。 还描述了获得细胞和使用它们的组合物的方法。