公开(公告)号：EP1764362A1

公开(公告)日：2007-03-21

申请号：EP05758117.5

申请日：2005-06-29

申请人： BANYU PHARMACEUTICAL CO., LTD.

发明人： KAWAMOTO, Hiroshi, Tsukuba Research Institute ,  ITO, Satoru, Tsukuba Research Institute ,  SATOH, Atsushi, Tsukuba Research Institute ,  NAGATOMI, Yasushi, Tsukuba Research Institute ,  HIRATA, Yukari, Tsukuba Research Institute ,  KIMURA, Toshifumi, Tsukuba Research Institute ,  SUZUKI, Gentaroh, Tsukuba Research Institute ,  SATO, Akio, Tsukuba Research Institute ,  OHTA, Hisashi, Tsukuba Research Institute

IPC分类号： C07D249/06 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61P9/10 ,  A61P25/04 ,  A61P25/08 ,  A61P25/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/36 ,  A61P29/00 ,  A61P43/00 ,  C07D271/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04

CPC分类号： C07D401/14 ,  C07D249/06 ,  C07D271/04 ,  C07D401/04 ,  C07D417/04

摘要： The present invention relates to a compound represented by the formula (I):

or a pharmaceutically acceptable salt thereof, whrein:
R 1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R 2 is halogen atom, a lower alkyl group, etc.; Q 1 is carbon atom or nitrogen atom; Q 2 is carbon atom which may be substituted with oxo group; the formula (III) :

is a single bond or a double bond; A is a group selected from the group consisting of the substituent group α; and R 5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，其中：R 1为直链或支链烷氧基，环烷氧基，直链或支链低级烷基等; R 2为卤素原子，低级烷基等; Q 1是碳原子或氮原子; Q 2是可被氧代基取代的碳原子; 式（III）：是单键或双键; A是选自由取代基组成的组的组; R 5为氢原子，低级烷基，氰基，烷氧基或三烷基甲硅烷基; 具有mGluR1抑制作用，并且可用作治疗和/或预防惊厥，急性疼痛，脑梗塞如脑梗死或暂时性脑缺血发作，焦虑，化学依赖或帕金森病。