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公开(公告)号:EP0397823B1
公开(公告)日:1999-01-07
申请号:EP89912312.9
申请日:1989-10-19
发明人: Pasquale, Samuel A.
IPC分类号: A61K31/565
CPC分类号: A61K31/565 , A61K2300/00
摘要: A method of contraception is disclosed which comprises a two-stage protocol. In the first stage, an estrogenic compound in a first composition is administered daily as the sole contraceptively active substance to a human female from about Day 2 to about Day 7 of her menstrual cycle, where Day 1 is the first day of menses. The second stage of the protocol occurs immediately thereafter during which at least one follow-up composition containing a progestin is administered daily to the same human female. The follow-up composition can contain a progestin as the sole contraceptively active ingredient, or can contain a combination of an estrogenic compound with a progestin in different weight ratios. A drug delivery system containing daily dosage units is also described.