公开(公告)号：EP2295427A1

公开(公告)日：2011-03-16

申请号：EP10185914.8

申请日：2005-05-02

申请人： Bayer HealthCare, LLC

发明人： Lee, Wendy ,  Ladouceur, Gaetan ,  Dumas, Jacques ,  Smith, Roger ,  Ying, Shihong ,  Wang, Gan ,  Chen, Zhi ,  Liu, Qingjie ,  Mokdad, Holia Hatoum

IPC分类号： C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  A61K31/535 ,  A61K31/435 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D405/14

摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).

wherein
R 1 and R 2 are independently:
(a) hydrogen;
(b) (C 1 -C 5 )alkyl, optionally substituted with one or more of hydroxy or fluoro; or
(c) halogen;
A is phenyl, pyridine, or pyrimidine, optionally substituted with 1 or 2 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen;
B is phenylene or naphthylene, optionally substituted with 1 to 4 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen;
L is a bridging group which is -O-, -S-, -CH 2 -.
M is phenyl, pyridine or pyrimidine, optionally substituted.

摘要翻译： 本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。 其中R 1和R 2独立地为：（a）氢; （b）（C 1 -C 5）烷基，任选被一个或多个羟基或氟取代; 或（c）卤素; A是苯基，吡啶或嘧啶，任选地被1或2个独立地为（C 1 -C 5）烷基，（C 1 -C 5）烷氧基，（C 1 -C 5）卤代烷基，（C 1 -C 5） C 5）卤代烷氧基或卤素; B是亚苯基或亚萘基，任选被1至4个独立地为（C 1 -C 5）烷基，（C 1 -C 5）烷氧基，（C 1 -C 5）卤代烷基，（C 1 -C 5） 卤代烷氧基或卤素; L是-O-，-S-，-CH 2 - 的桥接基团。 M是苯基，吡啶或嘧啶，任选被取代。

公开(公告)号：EP2295426A1

公开(公告)日：2011-03-16

申请号：EP10185804.1

申请日：2005-05-02

申请人： Bayer HealthCare, LLC

发明人： Lee, Wendy ,  Ladouceur, Gaetan ,  Dumas, Jacques ,  Smith, Roger ,  Ying, Shihong ,  Wang, Gan ,  Chen, Zhi ,  Liu, Qingjie ,  Mokdad, Holia Hatoum

IPC分类号： C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  A61K31/535 ,  A61K31/435 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D405/14

摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).

wherein
R 1 and R 2 are independently:
(a) hydrogen;
(b) (C 1 -C 5 )alkyl, optionally substituted with one or more of hydroxy or fluoro; or
(c) halogen;
A is phenyl, pyridine, or pyrimidine, optionally substituted with 1 or 2 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen;
B is phenylene or naphthylene, optionally substituted with 1 to 4 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen;
L is a bridging group which is -O-, -S-, or -CH 2 -
M is phenyl, pyridine or pyrimidine, optionally substituted.

摘要翻译： 本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。 其中R 1和R 2独立地为：（a）氢; （b）（C 1 -C 5）烷基，任选被一个或多个羟基或氟取代; 或（c）卤素; A是苯基，吡啶或嘧啶，任选地被1或2个独立地为（C 1 -C 5）烷基，（C 1 -C 5）烷氧基，（C 1 -C 5）卤代烷基，（C 1 -C 5） C 5）卤代烷氧基或卤素; B是亚苯基或亚萘基，任选被1至4个独立地为（C 1 -C 5）烷基，（C 1 -C 5）烷氧基，（C 1 -C 5）卤代烷基，（C 1 -C 5） 卤代烷氧基或卤素; L是-O-，-S-或-CH 2 - M是苯基，吡啶或嘧啶的任意取代的桥基。