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    Compositions and methods for producing antigen-presenting cells
    1.
    发明公开
    Compositions and methods for producing antigen-presenting cells 审中-公开
    Zusammensetzungen und Verfahren zur Herstellung vonAntigenpräsentierendenZellen

    公开(公告)号：EP2269629A2

    公开(公告)日：2011-01-05

    申请号：EP10010087.4

    申请日：2001-05-11

    申请人： Baylor Research Institute

    发明人： Bancheraeu, Jacques F. ,  Mohamadzadeh, Mansour ,  Palucka, Anna Karolina

    IPC分类号： A61K38/20 ,  A61K38/19 ,  A61K38/18 ,  C12N5/0784

    CPC分类号： C12N5/0639 ,  A61K2039/5154 ,  C12N2501/052 ,  C12N2501/056 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/25 ,  C12N2501/52

    摘要： The present invention relates to compositions and methods for producing antigen-presenting cells, in vitro, ex vivo or in vivo. This invention relates more particularly to methods and compositions for producing dendritic cells using interleukin-15, preferably in combination with a growth factor such as GM-CSF. This invention is particularly suited for producing immature dendritic cells and activated cells from precursors, in vitro, ex vivo or in vivo. The invention also relates to compositions for implementing these methods, as well as compositions comprising antigen-presenting cells and uses thereof. Dendritic cells or membrane vesicles derived thereforom have utility in many applications, including diagnostic, therapy, vaccination, research, screening and gene delivery.

    摘要翻译： 本发明涉及体外，离体或体内产生抗原呈递细胞的组合物和方法。 本发明更具体地涉及使用白细胞介素-15，优选与生长因子例如GM-CSF组合产生树突状细胞的方法和组合物。 本发明特别适于从体外，离体或体内从前体产生未成熟树突状细胞和活化细胞。 本发明还涉及用于实施这些方法的组合物，以及包含抗原呈递细胞的组合物及其用途。 衍生自其的树突状细胞或膜囊可用于许多应用，包括诊断，治疗，疫苗接种，研究，筛选和基因递送。

    Compositions and methods for producing antigen-presenting cells
    2.
    发明公开
    Compositions and methods for producing antigen-presenting cells 审中-公开
    Zusammensetzungen und Verfahren zur Herstellung von antigen-präsentierendenZellen

    公开(公告)号：EP1927657A2

    公开(公告)日：2008-06-04

    申请号：EP07016833.1

    申请日：2001-05-11

    申请人： Baylor Research Institute

    发明人： Banchereau, Jacques F. ,  Mohamadzadeh, Mansour ,  Palucka, Anna Karolina

    IPC分类号： C12N5/06 ,  C07K14/54 ,  C12N1/38 ,  A61K35/12

    CPC分类号： C12N5/0639 ,  A61K35/15 ,  A61K38/193 ,  A61K38/2086 ,  A61K2039/5154 ,  C12N2501/052 ,  C12N2501/056 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/25 ,  C12N2501/52 ,  A61K2300/00

    摘要： The present invention relates to compositions and methods for producing antigen-presenting cells, in vitro, ex vivo or in vivo. This invention relates more particularly to methods and compositions for producing dendritic cells using interleukin-15, preferably in combination with a growth factor such as GM-CSF. This invention is particularly suited for producing immature dendritic cells and activated cells from precursors, in vitro, ex vivo or in vivo. The invention also relates to compositions for implementing these methods, as well as compositions comprising antigen-presenting cells and uses thereof. Dendritic cells or membrane vesicles derived thereforom have utility in many applications, including diagnostic, therapy, vaccination, research, screening and gene delivery.

    摘要翻译： 本发明涉及体外，离体或体内产生抗原呈递细胞的组合物和方法。 本发明更具体地涉及使用白细胞介素-15，优选与生长因子例如GM-CSF组合产生树突状细胞的方法和组合物。 本发明特别适于从体外，离体或体内从前体产生未成熟树突状细胞和活化细胞。 本发明还涉及用于实施这些方法的组合物，以及包含抗原呈递细胞的组合物及其用途。 衍生自其的树突状细胞或膜囊可用于许多应用，包括诊断，治疗，疫苗接种，研究，筛选和基因递送。