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    BIODEGRADABLE AND RESORBABLE SURGICAL MATERIALS AND PROCESS FOR PREPARATION OF THE SAME
    2.
    发明公开
    BIODEGRADABLE AND RESORBABLE SURGICAL MATERIALS AND PROCESS FOR PREPARATION OF THE SAME 失效
    可生物降解和可吸收手术材料和方法它的过去。

    公开(公告)号：EP0349656A1

    公开(公告)日：1990-01-10

    申请号：EP89900920.3

    申请日：1988-12-27

    申请人： Biomaterials Universe, Inc. ,  TAKIRON CO. LTD.

    发明人： HYON, Suong-Hyu ,  IKADA, Yoshito ,  SHIKINAMI, Yasuo ,  TSUTA, Kaoru ,  BOUTANI, Hidekazu

    IPC分类号： A61L31/00

    CPC分类号： A61L31/148 ,  A61L31/06 ,  A61L31/14 ,  A61B17/58 ,  C08L67/04

    摘要： A surgical material which is dea absorbable in vivo comprising a molecularly of polylactic acid or a copolymer of acid, which has a compression bending strength at to 10 3 to 2.5 x 103 kg/cm 2 , compression bending models of 5 5 102 to 24.0 x 10 2 kg/mm 2 , a crystallinity of 10 to be as determined by densitometry, and a viscosity-average molecular weight of 200,000 or more after melt-molding and which can maintain 80 % or more of the initial strength even after being dipped in physiological saline at 370 for 3 months.

    摘要翻译： 一种外科材料所有这些是可降解的和可吸收的体内包含聚乳酸的分子取向模塑或乳酸与乙醇酸，其具有压缩的弯曲强度的共聚物1.6×10 <3>至2.5×10 <3>公斤/ 的厘米<2>，压缩弯曲模量5.5×10 <2>〜24.0×10 <2>千克/毫米<2>，10〜60％的结晶度由密度为确定性开采，和200,000的粘均分子量 或多个后熔融成形，并且可以甚至在37℃下的生理盐水中浸渍3个月后保持的初始强度的80％或更多。

    COMPOSITE POROUS MATERIAL
    3.
    发明公开
    COMPOSITE POROUS MATERIAL 有权
    ZUSAMMUSTRETZTESPORÖSES材料

    公开(公告)号：EP1932550A1

    公开(公告)日：2008-06-18

    申请号：EP06797910.4

    申请日：2006-09-13

    申请人： TAKIRON CO., LTD.

    发明人： SHIKINAMI, Yasuo

    IPC分类号： A61L27/00

    CPC分类号： A61L27/56 ,  A61L27/446 ,  A61L27/58

    摘要： A composite porous object which comprises a biodegradable and bioabsorbable polymer containing bioactive bioceramic particles dispersed therein, the composite porous object having in inner parts thereof large voids 1 having a void diameter of 40-600 µm and small voids 2 having a void diameter of 1 µm or smaller, at least part of the large voids 1 and at least part of the small voids 2 constituting interconnected voids.
    The small voids 2 are formed in the biodegradable and bioabsorbable polymer walls 3 which surround the large voids 1 and in the surface of the walls 3. It is preferred that 40% or more of all voids constitute interconnected voids.
    The walls 3 surrounding the large voids 1 in the composite porous object are progressively replaced by bone tissues conducting from the surface of the walls (internal surface of the large voids 1) to inner parts of the walls and by bone tissues conducting from the internal surface of the small voids 2 in the walls 3 toward surrounding parts. The degree of replacement by bone tissues is hence high, and the composite porous object is almost wholly replaced by bone tissues in the living body in a relatively short time period.

    摘要翻译： 一种复合多孔物体，其包含分散在其中的生物活性生物陶瓷颗粒的生物可降解和生物可吸收的聚合物，所述复合多孔物体在其内部具有空隙直径为40-600μm的大空隙1和空隙直径为1μm的小空隙2 或更小，至少部分大空隙1和构成互连空隙的小空隙2的至少一部分。 小空隙2形成在围绕大空隙1和壁3表面的可生物降解和生物可吸收的聚合物壁3中。优选所有空隙的40％或更多构成互连的空隙。 围绕复合多孔物体中的大空隙1的壁3逐渐地由从壁的表面（大空隙1的内表面）传导到壁的内部部分和从内表面传导的骨组织的骨组织 的壁3中的小空隙2朝向周围部分。 因此，骨组织的置换程度较高，复合多孔体几乎完全被生物体中的骨组织替代，在相当短的时间内。

    BIOMATERIAL FOR ARTIFICIAL CARTILAGES
    4.
    发明公开
    BIOMATERIAL FOR ARTIFICIAL CARTILAGES 审中-公开
    生物材料FÜRKÜNSTLICHEKNORPEL

    公开(公告)号：EP2228042A1

    公开(公告)日：2010-09-15

    申请号：EP08866000.6

    申请日：2008-12-25

    申请人： TAKIRON CO., LTD.

    发明人： SHIKINAMI, Yasuo

    IPC分类号： A61F2/44 ,  A61F2/30 ,  A61L27/00

    CPC分类号： A61L27/58 ,  A61F2/30756 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/442 ,  A61F2002/30009 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30131 ,  A61F2002/30492 ,  A61F2002/30784 ,  A61F2002/30841 ,  A61F2002/30971 ,  A61F2002/448 ,  A61F2002/4495 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2230/0013 ,  A61F2250/0019 ,  A61F2250/0028 ,  A61F2310/00179 ,  A61F2310/00592 ,  A61L27/34 ,  A61L27/427 ,  A61L27/50 ,  A61L2430/06

    摘要： An object of the present invention is to provide a biomaterial for an artificial cartilage that eliminates the risk of possible adverse effects due to scattering of fragments of the biodegradable and bioabsorbable polymers and is joined further solidly to vertebral bodies and the like with increased adhesiveness.
    The biomaterial for an artificial cartilage according to the present invention includes: an organized structure comprising organic fibers arranged in one of a multiaxial three-dimensional woven or knitted structure having three or more axes and a combined structure of the woven structure and the knitted structure; and a biodegradable and bioabsorbable pin provided inside the organized structure, two ends of the pin becoming projected from upper and lower surfaces of the organized structure upon compression on the organized structure from above and below, each of the upper and lower surfaces or either one of the surfaces of the organized structure having a superficial portion of a soft layer that is softer than the other portion of the organized structure, part or all of the organic fibers of the superficial portion being coated with a biodegradable and bioabsorbable polymer complex containing bioactive bioceramic powder. Adhesiveness with vertebral bodies and the like is increased by making the superficial portion(s) of the organized structure as a soft layer, the scattering of the polymers is prevented by coating the organic fibers of the superficial portion with the above complex, and the solid joint to vertebral bodies and the like is achieved.

    摘要翻译： 本发明的目的是提供一种人造软骨的生物材料，其消除了由于可生物降解和生物吸收性聚合物的碎片的散射而引起的可能的不利影响的风险，并且进一步牢固地连接到具有增加的粘附性的椎体等中。 根据本发明的人造软骨的生物材料包括：有机结构，其包括以具有三个或更多个轴的多轴三维织造或针织结构中的一个布置的织造结构和编织结构的组合结构; 以及设置在有组织结构内部的可生物降解和生物可吸收的销，销的两端在有组织的结构上从组合结构的上下表面突出，从上下各自的上下表面中，或者任一个 有组织结构的表面具有柔软层的表面部分，其比有组织结构的其它部分软，表层部分的有机纤维的部分或全部涂覆有生物可降解和生物可吸收的聚合物复合物，其含有生物活性生物陶瓷粉末 。 通过将有组织结构的表面部分作为软层来增加与椎体等的粘合性，通过用上述配合物涂布表面部分的有机纤维来防止聚合物的散射，并且固体 接合到椎体等。