公开(公告)号：EP2323994A1

公开(公告)日：2011-05-25

申请号：EP09780984.2

申请日：2009-07-23

申请人： Boehringer Ingelheim International GmbH

发明人： FANDRICK, Keith R. ,  GAO, Ju ,  LI, Wenjie ,  LU, Bruce ,  ZHANG, Yongda

IPC分类号： C07D265/10 ,  C07D413/06

CPC分类号： C07D265/10 ,  C07D413/06 ,  C07D413/10

摘要： Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).