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公开(公告)号：EP0240109B1
公开(公告)日：1990-12-12
申请号：EP87300938.5
申请日：1987-02-03
CPC分类号： A61K9/0068 , A61M31/002 , C22C23/04
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公开(公告)号：EP0482947B1
公开(公告)日：1996-03-06
申请号：EP91309890.1
申请日：1991-10-25
CPC分类号： A61K9/0092 , A61K9/0068 , C22C23/00
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公开(公告)号：EP0240109A1
公开(公告)日：1987-10-07
申请号：EP87300938.5
申请日：1987-02-03
CPC分类号： A61K9/0068 , A61M31/002 , C22C23/04
摘要： A pellet or bolus for administration to a ruminant by deposition in its rumeno-reticular sac where it is eroded away by rumen juices and releases active agent(s) and/or components, either continuously or in pulsed doses, comprises or incorporates a magnesium-based alloy which comprised at least 40% of magnesium, at least 30% zinc and up to 20% aluminium and, optionally, copper up to 5%, and trace elements, selected from cobalt, manganese, nickel and selenium up to 1 %, the percentages being by weight. A paste can be made by heating the alloy to between its solidus and liquidus points, when it can be admixed with lead shot for weighting the bolus.
In the illustrated case, the bolus comprises tubular sheath (14) which contains alloyliron shot filling (16). However, the alloy can be used for any appropriate component of the bolus.摘要翻译： 用于通过沉积在其瘤胃网状囊中向反刍动物施用的颗粒或丸剂，其中其被胃液侵蚀并且连续地或以脉冲剂量释放活性剂和/或组分，包含或掺入镁 - 其包含至少40％的镁，至少30％的锌和至多20％的铝，以及任选的至多5％的铜以及选自钴，锰，镍和硒至多1％的微量元素， 百分比以重量计。 可以通过将合金加热到其固相和液相点之间，当它可以与用于称重推注的铅射流混合时制成糊状物。 在所示的情况下，推注物包括管状护套（14），其包含合金/铁注射填充物（16）。 然而，该合金可用于推注的任何合适的组分。
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公开(公告)号：EP0482947A1
公开(公告)日：1992-04-29
申请号：EP91309890.1
申请日：1991-10-25
CPC分类号： A61K9/0092 , A61K9/0068 , C22C23/00
摘要： The invention provides a magnesium manganese alloy suitable for use in the production of a pellet 10 for administration to a ruminant by dposition in its rumeno-reticular sac. A typical pellet 10 comprises a magnesium alloy tube 12 enclosing a degradable core formed of plurality of tablets 14, 16. The magnesium alloy used in the construction comprises at least 90% by weight of magnesium, uyp to 1% zinc and up to 2% of manganese. Preferably the alloy may further include aluminium, silicon or zirconium along with iron and beryllium. When deposited in an animal's rumen the alloy reacts with the rumen juices to form an anodic film over the exposed surface of the tube 12. This prevents corrosion or dissolution of the tube 12 except at its exposed ends where galvanic corrosion by coupling with the electrically conductive core 14, 16 is provided. The normal requirement of a non-degradable exterior coating e.g. resin for the tube exterior is obviated.
摘要翻译： 本发明提供一种镁锰合金，其适用于生产颗粒10，用于通过在其瘤胃网状囊中分层给予反刍动物。 典型的颗粒10包括包围由多个片剂14,16形成的可降解芯的镁合金管12.用于该结构的镁合金包含至少90重量％的镁，u 1至1％的锌和至多2重量％ 的锰。 优选地，合金还可以包括铝，硅或锆以及铁和铍。 当沉积在动物瘤胃中时，合金与瘤胃汁反应以在管12的暴露表面上形成阳极膜。这防止了管12的腐蚀或溶解，除了其暴露的端部，其中电偶腐蚀通过与导电 芯14,16。 不可降解的外部涂层的正常要求，例如 用于管外表面的树脂被消除。
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公开(公告)号：EP0164927B1
公开(公告)日：1988-10-26
申请号：EP85303461.9
申请日：1985-05-17
IPC分类号： A61M31/00
CPC分类号： A61K9/0068 , A61M31/002
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公开(公告)号：EP0243111A2
公开(公告)日：1987-10-28
申请号：EP87303394.8
申请日：1987-04-16
CPC分类号： A61K9/0068 , A23K40/20 , A23K40/35 , A61J3/06 , A61M31/002
摘要： A pellet for administration to ruminants to supply magnesium and other biologically active material, for example, anthelmintics or antibiotics comrpises a tube of magnesium alloy (1) enclosing a core or filling (3). The core (3) typically comprises mainly iron shot as weighting material, a biologically active material if desired and an electrically conductive material such as carbon or graphite. The graphite ensures that the core (3) as a whole is conductive and provides a cathode electrically coupled with the magnesium alloy tube (1) to form a galvanic cell. Liquor in the rumen serves as an electrolyte to cause galvanic corrosion of the magnesium tube (1) to release the active material contained in the core (3). A protective coating (5) of resin is provided on the tube's exterior surface except on at least one end (4) so that the corrosion is limited to the exposed surfaces only. An alternative embodiment (Fig. 4) comprises a control magnesium alloy rod or shaft (11) around which a cylinder (13) of the electrically conductive component is pressed. The cylinder contain iron shot and graphite in similar proportions to the core (3) in the first embodiment and is also provided with a protective resin coating (12) to restrict corrosion to one or both ends of the rod (11).
摘要翻译： 用于向反刍动物施用供应镁和其他生物活性物质的丸剂，例如驱虫剂或抗生素包含一个包围核心或填充物（3）的镁合金管（1）。 核心（3）通常主要包括作为加重材料的铁丸，如果需要的话，生物活性材料和导电材料如碳或石墨。 该石墨确保核心（3）整体上是导电的并且提供与镁合金管（1）电耦合的阴极以形成原电池。 瘤胃中的酒液作为电解液引起镁管（1）的电镀腐蚀，以释放包含在芯体（3）中的活性物质。 除了至少一端（4）之外，在管的外表面上提供树脂保护涂层（5），以使腐蚀仅限于暴露的表面。 替代实施例（图4）包括控制镁合金棒或轴（11），导电部件的气缸（13）被压在该控制镁合金杆或轴上。 圆筒包含与第一实施例中的芯（3）相似比例的铁丸和石墨，并且还设置有保护树脂涂层（12）以限制杆（11）的一端或两端的腐蚀。
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7.发明公开Zinc based alloy bolus for veterinary use 审中-公开Bolus aus einer Zinklegierung bestimmtfürtierärzlicheVerwendung
公开(公告)号：EP1225238A1
公开(公告)日：2002-07-24
申请号：EP01310881.6
申请日：2001-12-24
摘要： A metal alloy comprising, by weight of the total weight of the alloy:
(a) at least 50wt% of zinc;
(b) from 30 to 49wt% of magnesium; and
(c) up to 6wt% of copper,
and a bolus comprising such an alloy, as well as the use of this alloy in the preparation of a medicament for the treatment or prevention of facial eczema, foot rot or hypomagnesaemia in an animal.摘要翻译： 一种金属合金，其以合金的总重量的重量计含有：（a）至少50wt％的锌; （b）30〜49重量％的镁; 和（c）至多6重量％的铜，以及包含这种合金的推注剂，以及该合金在制备用于治疗或预防动物中的面部湿疹，脚腐烂或低镁血症的药物中的用途。
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公开(公告)号：EP0243111A3
公开(公告)日：1989-06-07
申请号：EP87303394.8
申请日：1987-04-16
CPC分类号： A61K9/0068 , A23K40/20 , A23K40/35 , A61J3/06 , A61M31/002
摘要： A pellet for administration to ruminants to supply magnesium and other biologically active material, for example, anthelmintics or antibiotics comrpises a tube of magnesium alloy (1) enclosing a core or filling (3). The core (3) typically comprises mainly iron shot as weighting material, a biologically active material if desired and an electrically conductive material such as carbon or graphite. The graphite ensures that the core (3) as a whole is conductive and provides a cathode electrically coupled with the magnesium alloy tube (1) to form a galvanic cell. Liquor in the rumen serves as an electrolyte to cause galvanic corrosion of the magnesium tube (1) to release the active material contained in the core (3). A protective coating (5) of resin is provided on the tube's exterior surface except on at least one end (4) so that the corrosion is limited to the exposed surfaces only. An alternative embodiment (Fig. 4) comprises a control magnesium alloy rod or shaft (11) around which a cylinder (13) of the electrically conductive component is pressed. The cylinder contain iron shot and graphite in similar proportions to the core (3) in the first embodiment and is also provided with a protective resin coating (12) to restrict corrosion to one or both ends of the rod (11).
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公开(公告)号：EP0140632B1
公开(公告)日：1989-02-01
申请号：EP84307033.5
申请日：1984-10-15
CPC分类号： A61K9/0068 , A61J3/06 , A61M31/002
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公开(公告)号：EP0140632A2
公开(公告)日：1985-05-08
申请号：EP84307033.5
申请日：1984-10-15
CPC分类号： A61K9/0068 , A61J3/06 , A61M31/002
摘要： A pellet for administration into and reside in the rumeno-reticular sac of a ruminant and to release successive doses of an active agent, such as an anthelmentic, comprises an assembly (10) of discs (12) each having a peripheral skirt (14) on one side and an inwardly-spaced skirt (16) on the other so that such discs can interfit by said skirts (14, 16) and define therebetween cavities (18) each containing a respective active agent dose (24). A weighting slug (20) is provided at one end of the assembly (10) which is enclosed except at one end by a surrounding plastics sheath (26) so that rumen juices may attack and erode the successive discs (12) to release the successive doses (24). The discs (12) are of a magnesium-based alloy and the slug (20) is of a Zinc-based alloy.
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