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1.发明公开Cholesterol-lowering agents and veterinary cholesterol-lowering agents 失效Den。。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：EP0462021A2
公开(公告)日：1991-12-18
申请号：EP91401622.5
申请日：1991-06-17
发明人： Soma, Gen'Ichiro , Yoshimura, Kiyoshi , Tsukioka, Daisuke , Mizuno, Den'Ichi , Oshima, Haruyuki
CPC分类号： A61K36/02 , A61K36/06 , A61K36/07 , A61K36/899 , A61K2300/00
摘要： A cholesterol-lowering composition comprising an effective amount of at least one member of LPS whose macrophage activation ED₅₀ is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro , and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and
a method of treating high cholesterol level of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the high cholesterol level of said animal.摘要翻译： 一种胆固醇降低组合物，其包含有效量的至少一种LPS成分，其巨噬细胞活化ED 50为0.4-100ng / ml培养液，其鲎试验阳性LPS含量在通过测定能力制备的乙状曲线上观察到 的LPS以激活体外培养的巨噬细胞的TNF生产力，并绘制沿纵坐标轴的巨噬细胞活化能力（％），其中在对应于由TNFα产生的TNF的量的情况下，该能力估计为0％ 没有添加LPS的巨噬细胞，100％被赋予巨噬细胞活化能力，其提供由巨噬细胞产生的TNF的最大和恒定量，并沿着横坐标绘制LPS的鲎试验阳性LPS含量为对数 与药学或兽医学上可接受的载体混合，使得当施用于动物时，所述动物的高胆固醇水平是预先 通风或治愈; 以及治疗动物的高胆固醇水平的方法，包括向所述动物施用一定量的上述有效预防或治愈所述动物的高胆固醇水平的组合物。
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公开(公告)号：EP0462021A3
公开(公告)日：1992-04-29
申请号：EP91401622.5
申请日：1991-06-17
发明人： Soma, Gen'Ichiro , Yoshimura, Kiyoshi , Tsukioka, Daisuke , Mizuno, Den'Ichi , Oshima, Haruyuki
CPC分类号： A61K36/02 , A61K36/06 , A61K36/07 , A61K36/899 , A61K2300/00
摘要： A cholesterol-lowering composition comprising an effective amount of at least one member of LPS whose macrophage activation ED₅₀ is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro , and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and
a method of treating high cholesterol level of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the high cholesterol level of said animal.
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