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    Vascularization inhibitors
    2.
    发明公开
    Vascularization inhibitors 审中-公开
    血管抑制剂

    公开(公告)号：EP1745797A3

    公开(公告)日：2007-07-18

    申请号：EP06013016.8

    申请日：1999-03-23

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA ,  Kishimoto, Tadamitsu

    发明人： Kishimoto, Tadamitsu ,  Nagasawa, Takashi ,  Tachibana, Kazunobu

    IPC分类号： A61K45/00 ,  A61K39/395 ,  A61K48/00 ,  A61K31/70 ,  A61K31/56 ,  A61K38/43 ,  A61P35/00 ,  A61K35/00

    CPC分类号： G01N33/5011 ,  A61K38/1793

    摘要： This invention provides a therapeutic agent for inhibiting neovascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, and a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4.
    Based on the finding that vascularization is suppressed in CXCR4 knockout mice, it becomes possible to prepare a therapeutic agent for suppressing vascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, each of which comprises as the effective ingredient, a substance that inhibits the action of CXCR4, as well as to prepare a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. By using these substances, treatments are made possible.

    Vascularization inhibitors
    4.
    发明公开
    Vascularization inhibitors 审中-公开
    抑制剂

    公开(公告)号：EP1745797A2

    公开(公告)日：2007-01-24

    申请号：EP06013016.8

    申请日：1999-03-23

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA ,  Kishimoto, Tadamitsu

    发明人： Kishimoto, Tadamitsu ,  Nagasawa, Takashi ,  Tachibana, Kazunobu

    IPC分类号： A61K38/16 ,  A61K39/395 ,  A61P35/00

    CPC分类号： G01N33/5011 ,  A61K38/1793

    摘要： This invention provides a therapeutic agent for inhibiting neovascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, and a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4.
    Based on the finding that vascularization is suppressed in CXCR4 knockout mice, it becomes possible to prepare a therapeutic agent for suppressing vascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, each of which comprises as the effective ingredient, a substance that inhibits the action of CXCR4, as well as to prepare a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. By using these substances, treatments are made possible.

    摘要翻译： 本发明提供抑制新血管形成的治疗剂，固体癌治疗剂，由新血管形成病理性引起的疾病的治疗剂，以及用于修复作为有效成分的组织的治疗剂， CXCR4。 基于在CXCR4敲除小鼠中血管形成被抑制的发现，可以制备抑制血管形成的治疗剂，固体癌治疗剂，由新血管形成病理性引起的疾病的治疗剂，其各自为 有效成分，抑制CXCR4作用的物质，以及制备用于修复包含作为有效成分的组织的治疗剂，其是增强CXCR4作用的物质。 通过使用这些物质，可以进行治疗。