公开(公告)号：EP3563875A1

公开(公告)日：2019-11-06

申请号：EP18170735.7

申请日：2018-05-04

申请人： Ceské vysoké ucení technické v Praze ,  UJV Rez, A.S.

发明人： Kozempel, Ján ,  Vlk, Martin ,  Mi olová, Petra ,  Kukleva, Ekaterina ,  Jandová, Ludmila ,  Merhautová, Hana ,  Ficenzová, Karolína

IPC分类号： A61K51/02 ,  A61K51/12

摘要： The present invention relates to a set for radionuclide therapy, comprising a component A and a component B, for use in the treatment of bone diseases by administration of the component B in a dosage ensuring a higher than physiological concentration of a substance affecting Ca 2+ metabolism in the organism and/or in the compartment treated, and co-administration of the component A, wherein the component A comprises a water-soluble radium salt containing at least one radionuclide of radium, and the component B comprises at least one substance affecting Ca 2+ metabolism in the organism, selected from the group comprising water-soluble salts of alkaline earth metals, calciferols, calcitonins, thyroid and parathyroid gland hormones, amino acids and salts thereof, peptides having a chain length of 2 to 100 amino acids and salts thereof, bisphosphonates of the general formula (I),

wherein R 1 is -H, -OH, -Cl;
R 2 is -CH 3 , -Cl, -CH 2 CH 2 NH 2 , -(CH 2 ) 5 -NH 2 , -(CH 2 ) 3 -NH 2 ,

CH 2 CH 2 N(CH 3 )-(CH 2 ) 4 CH 3 ;
and combinations thereof.