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    THE PREPARATION METHOD OF (3S,4S)-3-HEXYL-4-((R)-2-HYDROXYTRIDECYL)-OXETAN-2-ONE AND THE PRODUCT OF THAT METHOD
    1.
    发明公开
    THE PREPARATION METHOD OF (3S,4S)-3-HEXYL-4-((R)-2-HYDROXYTRIDECYL)-OXETAN-2-ONE AND THE PRODUCT OF THAT METHOD 有权
    VERFAHREN ZUR HERSTELLUNG VON（3S，4S）-3-HEXYL-4 - （（R）-2-羟基吡啶）OXETAN-2-ON UND DAS PRODUKT DIESES VERFAHRENS

    公开(公告)号：EP2280007A1

    公开(公告)日：2011-02-02

    申请号：EP08757494.3

    申请日：2008-05-26

    申请人： Chongqing Zhien Pharmaceutical Co., Ltd. ,  Sichuan University

    发明人： QIN, Yong ,  DENG, Xianglin ,  ZHOU, Xuan ,  YU, Guofeng ,  WANG, Ke ,  SONG, Hao ,  WANG, Xiaolin ,  HUANG, Shan

    IPC分类号： C07D305/12

    CPC分类号： C07D305/12 ,  C07D213/70

    摘要： The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.

    摘要翻译： 本发明涉及制备（3S，4S）-3-己基-4 - （（R）-2-羟基十三烷基） - 氧杂环丁烷-2-酮的方法和该方法的产物。 该方法包括以下步骤：a）还原由式（II）表示的物质以获得由式（III）表示的物质，然后氧化由式（III）表示的物质以形成由式（IV）表示的物质， ; b）用正辛酸酰化得到正辛酰氯，然后在碱性条件下将所得正辛酰氯与2-巯基 - 吡啶缩合形成式（Ⅴ）表示的物质，然后转化成物质 由式（Ⅴ）代表由式（Ⅵ）表示的物质; c）在路易斯酸的催化条件下，使步骤a）中获得的物质与步骤b）中获得的物质反应，生成由式（Ⅶ）表示的物质，然后与路易斯酸反应。 这些公式中的符号的含义与描述中的符号的含义相同。