公开(公告)号：EP1414836A2

公开(公告)日：2004-05-06

申请号：EP02764788.2

申请日：2002-07-25

申请人： Clariant Life Science Molecules (Italia) SpA

发明人： FRIGERIO, Marco ,  BANFI, Aldo ,  DALL'ORO, Bruno ,  MANCINI, Alfredo

IPC分类号： C07H19/056 ,  C07H1/00 ,  A61K31/7056 ,  A61P31/12

CPC分类号： C07H19/056 ,  C07H1/00

摘要： A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula with a protected ribofuranose of the formula b) the removal of the Pg groups and, optionally, the conversion into a carhoxyamide group of the R2 group of the compound obtained of the formula

摘要翻译： 描述了工业规模制备利巴韦林的方法，其包括在路易斯酸存在下3-取代三唑的糖基化反应。 所述方法包括：a）使下式的三唑与式b的被保护的呋喃核糖反应b）除去Pg基团，并且任选地转化为式I所得化合物的R2基团的羧酰胺基团

公开(公告)号：EP1414836B1

公开(公告)日：2004-12-29

申请号：EP02764788.2

申请日：2002-07-25

申请人： Clariant Life Science Molecules (Italia) SpA

发明人： FRIGERIO, Marco ,  BANFI, Aldo ,  DALL'ORO, Bruno ,  MANCINI, Alfredo

IPC分类号： C07H19/056 ,  C07H1/00 ,  A61K31/7056 ,  A61P31/12

CPC分类号： C07H19/056 ,  C07H1/00

摘要： A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula with a protected ribofuranose of the formula b) the removal of the Pg groups and, optionally, the conversion into a carhoxyamide group of the R2 group of the compound obtained of the formula