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公开(公告)号：EP2970305A1
公开(公告)日：2016-01-20
申请号：EP14723919.8
申请日：2014-03-12
发明人： ALBRECHT, Brian, K. , AUDIA, James, Edmund , COOK, Andrew , CÔTÉ, Alexandre , DAKIN, Les, A. , GEHLING, Victor, S. , HARMANGE, Jean-Christophe , NASVESCHUK, Christopher, G. , VASWANI, Rishi, G.
IPC分类号： C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
摘要翻译： 剂用于调制甲基修饰酶，组合物及其用途中提供。
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公开(公告)号：EP4421072A1
公开(公告)日：2024-08-28
申请号：EP24160308.3
申请日：2019-04-17
IPC分类号： C07D405/14 , C07D405/12 , A61K31/44 , A61P35/00
CPC分类号： C07D405/12 , C07D405/14 , A61P35/00
摘要： Provided are novel compounds of Formula (I):
and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.-
公开(公告)号：EP3781561A1
公开(公告)日：2021-02-24
申请号：EP19722363.9
申请日：2019-04-17
IPC分类号： C07D405/14 , C07D405/12 , A61K31/44 , A61P35/00
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公开(公告)号：EP2646446B1
公开(公告)日：2015-05-13
申请号：EP11844513.9
申请日：2011-12-02
发明人： ALBRECHT, Brian K. , AUDIA, James Edmund , CÔTÉ, Alexandre , GEHLING, Victor S. , HARMANGE, Jean-christophe , HEWITT, Michael C. , LEBLANC, Yves , NASVESCHUK, Christopher G. , TAYLOR, Alexander M. , VASWANI, Rishi G.
IPC分类号： C07D498/04 , C07D498/14 , A61K31/55 , A61K31/424 , A61P35/00
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
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公开(公告)号：EP2721031B1
公开(公告)日：2016-01-20
申请号：EP12799791.4
申请日：2012-06-15
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025
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公开(公告)号：EP2646446A2
公开(公告)日：2013-10-09
申请号：EP11844513.9
申请日：2011-12-02
发明人： ALBRECHT, Brian K. , AUDIA, James Edmund , CÔTÉ, Alexandre , GEHLING, Victor S. , HARMANGE, Jean-christophe , HEWITT, Michael C. , LEBLANC, Yves , NASVESCHUK, Christopher G. , TAYLOR, Alexander M. , VASWANI, Rishi G.
IPC分类号： C07D498/04 , C07D498/14 , A61K31/55 , A61K31/424 , A61P35/00
CPC分类号： C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及用作含溴结构域蛋白抑制剂的化合物。 本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用所述组合物治疗各种疾病的方法。
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公开(公告)号：EP3797108A1
公开(公告)日：2021-03-31
申请号：EP19733214.1
申请日：2019-05-17
IPC分类号： C07D491/056 , A61K31/4741 , A61P35/00
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公开(公告)号：EP2970305B1
公开(公告)日：2017-02-22
申请号：EP14723919.8
申请日：2014-03-12
发明人： ALBRECHT, Brian, K. , AUDIA, James, Edmund , COOK, Andrew , CÔTÉ, Alexandre , DAKIN, Les, A. , GEHLING, Victor, S. , HARMANGE, Jean-Christophe , NASVESCHUK, Christopher, G. , VASWANI, Rishi, G.
IPC分类号： C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2721031A2
公开(公告)日：2014-04-23
申请号：EP12799791.4
申请日：2012-06-15
IPC分类号： C07D487/04 , C07D403/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025
摘要： The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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