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公开(公告)号：EP3572061A1
公开(公告)日：2019-11-27
申请号：EP17893313.1
申请日：2017-12-21
发明人： KOMAZAWA, Kozue , HIGUCHI, Tatsuya , KIGAWA, Koji , OBATA, Kazuaki , DEMPO, Takayuki , NISHIMURA, Masuhiro
摘要： There is provided a container or an equipment having low-protein adsorption properties, to be used for administering, storing, conveying or transporting protein or a composition including protein, or for producing protein or a composition including protein. A container or an equipment for producing protein or a composition including protein, wherein the surface of the container or the equipment in contact with protein or a composition including protein is formed of a fluororesin which is at least one fluororesin selected from a tetrafluoroethylene-hexafluoropropylene-based copolymer and a tetrafluoroethylene-perfluoroalkylvinyl ether-based copolymer, which has a melting point of 320°C or less and which has a total number of non-fluorinated group terminals and -CF 2 H group terminals in the fluororesin of 70 or less per 1 × 10 6 carbon atoms, has remarkable low-protein adsorption properties. Such a container or equipment can be used to thereby, for example, prevent, in a producing (culturing and purifying, and the like) step, a storing and delivering step and/or administration of a protein formulation such as an antibody pharmaceutical product, the protein formulation from being lost due to adsorption thereof to the equipment.
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公开(公告)号：EP3323878A1
公开(公告)日：2018-05-23
申请号：EP16824084.4
申请日：2016-07-14
IPC分类号： C12M3/00
CPC分类号： C12M23/20 , A61K35/28 , C09D127/18 , C09D127/20 , C09D129/10 , C12M23/14 , C12N5/0663
摘要： When mammal cells are administered by using a container whose surface in contact with the mammal cells is formed of a fluororesin material at least partially having a -CF 3 terminal group or a container whose surface in contact with the mammal cells is formed of a fluororesin material having a total number of non-fluorinated group terminals and -CF 2 H group terminals in the fluororesin of 70 or less per 1 × 10 6 carbon atoms, or mammal cells are stored or cultured in such a container, the cell adhesion on the container inner surface and the cell survival rate reduction can effectively be suppressed. Therefore, by using these containers, a mammal cell-containing liquid having a high concentration and a high proportion of living cells can be administered, stored or prepared, which contributes to regenerative medicine using the mammal cell-containing liquid (suspension liquid).
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