公开(公告)号：EP3202414A1

公开(公告)日：2017-08-09

申请号：EP16205563.6

申请日：2005-09-22

申请人： Dyax Corp.

发明人： Ladner,, Robert C ,  Ley,, Arthur C ,  Hirani,, Shirish ,  Williams,, Anthony ,  De Simoni,, Maria Grazia ,  Bergamaschini,, Luigi ,  Blair,, Henry ,  Beck,, Thomas

IPC分类号： A61K38/17 ,  A61K31/195 ,  A61K38/48 ,  A61K38/55 ,  A61K45/06

CPC分类号： A61K38/55 ,  A61K31/195 ,  A61K38/57 ,  A61K45/06 ,  A61K2300/00

摘要： Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass. Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient by administering a kalliekrein inhibitor.

摘要翻译： 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂（例如抗纤维蛋白溶解剂）的方法，试剂盒和组合物，用于预防或减少失血和/或缺血，例如与围手术期失血相关的局部缺血 和脑缺血，全身炎症反应的发作和/或再灌注损伤，例如与脑缺血或局灶性脑缺血相关的再灌注损伤，例如在经历侵入性外科手术的患者中，尤其是需要体外循环的手术。 描述了通过施用激肽释放酶抑制剂来预防或减少患者的局部缺血，例如脑缺血和/或再灌注损伤（例如与脑缺血相关的再灌注损伤）的方法。