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公开(公告)号：EP2336184A3
公开(公告)日：2012-01-11
申请号：EP10012870.1
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
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公开(公告)号：EP2360185A3
公开(公告)日：2012-01-11
申请号：EP10012871.9
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
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公开(公告)号：EP2336184A2
公开(公告)日：2011-06-22
申请号：EP10012870.1
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
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公开(公告)号：EP2289941A3
公开(公告)日：2012-01-18
申请号：EP10012872.7
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
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公开(公告)号：EP2289941A2
公开(公告)日：2011-03-02
申请号：EP10012872.7
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
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公开(公告)号：EP2360185A2
公开(公告)日：2011-08-24
申请号：EP10012871.9
申请日：2003-02-25
发明人： Taylor, Julie , Yednock, Ted A.
IPC分类号： C07K16/28 , A61K39/395 , G01N33/533 , G01N33/53 , A61P1/04 , A61P37/02 , A61P25/02
CPC分类号： C07K16/2839 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2842 , C07K2317/24 , C07K2317/76 , G01N33/56966 , G01N2333/4737 , G01N2333/7055
摘要： A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation.
摘要翻译： 公开了通过施用特异性结合α-4整联蛋白或包含α-4整联蛋白的二聚体的试剂来长期减少患者的病理性炎症的方法。 提供的试剂必须具有结合亲和力，以便施用足以抑制病理性炎症，并且该试剂长期施用以提供对病理性炎症的长期抑制。
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