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1.发明授权
公开(公告)号：EP3478686B1
公开(公告)日：2020-04-15
申请号：EP17732454.8
申请日：2017-06-26
发明人： CHENG, Zhanling , HAN, Xingchun , JIANG, Min , YANG, Song
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P31/20
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公开(公告)号：EP3292120B1
公开(公告)日：2019-06-19
申请号：EP16719863.9
申请日：2016-05-02
发明人： CHENG, Zhanling , HAN, Xingchun , JIANG, Min , WANG, Jianhua , WANG, Min , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P31/20
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公开(公告)号：EP3328855B1
公开(公告)日：2019-05-15
申请号：EP16750408.3
申请日：2016-07-25
发明人： HAN, Xingchun , JIANG, Min , WANG, Yongguang , YANG, Song
IPC分类号： C07D455/06 , C07D471/14 , C07D491/147 , C07D495/14 , A61K31/4745 , A61P31/20
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公开(公告)号：EP3478680A1
公开(公告)日：2019-05-08
申请号：EP17733806.8
申请日：2017-06-26
发明人： CHENG, Zhanling , HAN, Xingchun , JIANG, Min , WANG, Jianhua , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , C07D519/00 , A61K31/519 , A61P31/20
摘要： The present invention provides novel compounds having general formula (I), wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.
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5.发明公开NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开新型6,7-二氢苯并[A]喹啉-2-酮衍生物用于乙型肝炎病毒感染的治疗和预防
公开(公告)号：EP3215504A1
公开(公告)日：2017-09-13
申请号：EP15795124.5
申请日：2015-10-30
发明人： HAN, Xingchun , JIANG, Min , WANG, Jianhua , ZHOU, Chengang , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/20
CPC分类号： C07D471/04
摘要： The invention provides novel compounds having the general formula: wherein R1 to R6, W and X are as described herein and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新颖化合物：其中R 1至R 6，W和X如本文所述，及其药学上可接受的盐，对映体或非对映体，以及包含所述化合物的组合物和使用所述化合物的方法。
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公开(公告)号：EP3215504B1
公开(公告)日：2019-08-21
申请号：EP15795124.5
申请日：2015-10-30
发明人： HAN, Xingchun , JIANG, Min , WANG, Jianhua , ZHOU, Chengang , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/20
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7.发明公开NOVEL 2-OXO-6,7-DIHYDROBENZO[A]QUINOLIZINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开新型2-OXO-6,7-二氢苯并[A]喹啉-3-羧酸衍生物用于治疗和预防乙型肝炎病毒感染
公开(公告)号：EP3256471A1
公开(公告)日：2017-12-20
申请号：EP16703311.7
申请日：2016-02-08
发明人： HAN, Xingchun , JIANG, Min , YANG, Song
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： C07D471/04
摘要： wherein R1, R2, R3, R4, R5 and Ar are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：EP3478680B1
公开(公告)日：2020-04-22
申请号：EP17733806.8
申请日：2017-06-26
发明人： CHENG, Zhanling , HAN, Xingchun , JIANG, Min , WANG, Jianhua , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , C07D519/00 , A61K31/519 , A61P31/20
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公开(公告)号：EP3328855A1
公开(公告)日：2018-06-06
申请号：EP16750408.3
申请日：2016-07-25
发明人： HAN, Xingchun , JIANG, Min , WANG, Yongguang , YANG, Song
IPC分类号： C07D455/06 , C07D471/14 , C07D491/147 , C07D495/14 , A61K31/4745 , A61P31/20
CPC分类号： C07D471/14 , A61P31/20 , C07D455/06 , C07D491/147 , C07D495/14
摘要： wherein R1 to R6, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.
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10.发明公开TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS 审中-公开作为HBSAG（HBV表面抗原）抑制剂和HBV DNA生产的四氢吡啶嘧啶类化合物和四氢吡啶并吡啶类化合物治疗乙型肝炎病毒感染
公开(公告)号：EP3292120A1
公开(公告)日：2018-03-14
申请号：EP16719863.9
申请日：2016-05-02
发明人： CHENG, Zhanling , HAN, Xingchun , JIANG, Min , WANG, Jianhua , WANG, Min , WANG, Yongguang , YANG, Song
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P31/20
CPC分类号： C07D471/04 , A61P31/20
摘要： The present invention provides tetrahydropyridopyrimidines and tetrahydropyridopyridines having the general formula (I) wherein R1, R2, U, W, X, Y and Z are as described herein, as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment and prophylaxis of hepatitis B virus infections.
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