公开(公告)号：EP0943327A1

公开(公告)日：1999-09-22

申请号：EP97946111.8

申请日：1997-12-05

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： HATA, Takehisa ,  TOKUNAGA, Yuji ,  SHIMOJO, Fumio ,  KIMURA, Sumihisa ,  HIROSE, Takeo ,  UEDA, Satoshi

IPC分类号： A61K9/14 ,  A61K31/335

CPC分类号： A61K9/145 ,  A61K9/146

摘要： To provide a pharmaceutical composition comprising a water-insoluble active substance, surfactant(s) and solid carrier(s), which is improved in dissolution and oral absorption characteristics.

摘要翻译： 提供包含水溶性活性物质，表面活性剂和固体载体的药物组合物，其溶出度和口服吸收特性得到改善。

公开(公告)号：EP0851753B1

公开(公告)日：2003-11-19

申请号：EP96931227.1

申请日：1996-09-18

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： MURATA, Saburo ,  SHIMOJO, Fumio ,  TOKUNAGA, Yuji ,  HATA, Takehisa

IPC分类号： A61K9/00

CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K31/4433

公开(公告)号：EP0851753A1

公开(公告)日：1998-07-08

申请号：EP96931227.0

申请日：1996-09-18

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： MURATA, Saburo ,  SHIMOJO, Fumio ,  TOKUNAGA, Yuji ,  HATA, Takehisa

IPC分类号： A61K9 ,  A61K31 ,  A61K38 ,  A61K45 ,  A61K47 ,  A61P11 ,  A61P31 ,  A61P37 ,  A61P43 ,  C07D498

CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K31/4433

摘要： The use of a medium-chain fatty acid triglyceride as the dispersant in the preparation of a medicinal aerosol composition comprising tricyclic compound (I) dispersed in a liquefied hydrofluoroalkane propellant is described. When a liquefied hydrofluoroalkane is added to a kneaded premix of the tricyclic compound (I) and a medium-chain fatty acid triglyceride, the active ingredient is evenly dispersed in the liquefied hydrofluoroalkane. Therefore, by distributing a dispenser first with the kneaded premix and, then, with a liquefied hydrofluoroalkane under cooling or elevated pressure, there can be provided a medicinal aerosol composition having an improved uniformity of content of the active ingredient.