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    Cephalosporin antibiotics
    2.
    发明公开
    Cephalosporin antibiotics 失效
    头孢菌素抗生素

    公开(公告)号：EP0181172A3

    公开(公告)日：1988-06-01

    申请号：EP85307950

    申请日：1985-11-01

    申请人： GLAXO GROUP LIMITED

    发明人： Bell, Richard ,  Foxton, Michael Walter ,  Looker, Brian Edgar

    IPC分类号： C07D501/24 ,  C07D277/20 ,  A61K31/545

    CPC分类号： C07D277/587 ,  Y02P20/55

    摘要： Compounds of general formula (I)

    (where R' is a carboxyl group, a group COO ⊖ or a blocked carboxyl group;
    R 2 is an amino or protected amino group; and R is hydrogen or a group of the formula CH 2 X, where X represents a halogen atom, a hydroxyl group, an acetoxy group; a group of the formula O.CO.NHR 3 , where R 3 is hydrogen, a C 1-4 alkyl group optionally substituted by 1 to 3 halogen atoms or an N-protecting group; a group of the formula OR 4 , where R" is a C 1-4 alkyl group optionally substituted by halogen or a C 1-4 alkoxy group; or a pyridinium, 3-carbamoylpyridinium or 4-carbamoyl-pyridinium group; B is -S- or -SO- (a- or β-); and the dotted line bridging the 2-, 3- and 4- positions indicates that the compound is a ceph-2-em or ceph-3-em compound) and salts thereof, the compounds of formula (I) being associated with an anion when X represents a pyridinium, 3-carbamoylpyridinium group or a 4-carbamoylpyridinium group and R' is other than COO ⊖ ) are disclosed. Processes for their preparation and pharmaceutical compositions containing them are also disclosed.

    摘要翻译： 通式（I）的化合物（其中R'为羧基，基团COO 8或封端的羧基; R 2为氨基或被保护的氨基;且R为氢或式CH 2 X的基团，其中X代表 卤素原子，羟基，乙酰氧基;式O.CO.NHR 3的基团，其中R 3是氢，任选被1至3个卤素原子取代的C 1-4烷基或N-保护基团; 其中R“为任选被卤素或C1-4烷氧基取代的C1-4烷基;或吡啶鎓，3-氨基甲酰基吡啶鎓或4-氨基甲酰基 - 吡啶鎓基团; B为-S-或 - SO-（α-或β-）;桥接2-，3-和4-位置的虚线表明化合物是ceph-2-em或ceph-3-em化合物）及其盐，化合物 当X代表吡啶鎓，3-氨基甲酰基吡啶鎓基团或4-氨基甲酰基吡啶鎓基团且R'不是COO时，式（I）的化合物与阴离子缔合） 还公开了含有它们的药物组合物和药物组合物。

    Cephalosporin antibiotics
    4.
    发明公开
    Cephalosporin antibiotics 失效
    头孢菌素Antibiotika。

    公开(公告)号：EP0181172A2

    公开(公告)日：1986-05-14

    申请号：EP85307950.7

    申请日：1985-11-01

    申请人： GLAXO GROUP LIMITED

    发明人： Bell, Richard ,  Foxton, Michael Walter ,  Looker, Brian Edgar

    IPC分类号： C07D501/24 ,  C07D277/20 ,  A61K31/545

    CPC分类号： C07D277/587 ,  Y02P20/55

    摘要： Compounds of general formula (I)

    (where R' is a carboxyl group, a group COO ⊖ or a blocked carboxyl group;

    R 2 is an amino or protected amino group; and
    R is hydrogen or a group of the formula CH 2 X, where X represents a halogen atom, a hydroxyl group, an acetoxy group; a group of the formula O.CO.NHR 3 , where R 3 is hydrogen, a C 1-4 alkyl group optionally substituted by 1 to 3 halogen atoms or an N-protecting group; a group of the formula OR 4 , where R" is a C 1-4 alkyl group optionally substituted by halogen or a C 1-4 alkoxy group; or a pyridinium, 3-carbamoylpyridinium or 4-carbamoyl-pyridinium group;
    B is -S- or -SO- (a- or β-); and the dotted line bridging the 2-, 3- and 4- positions indicates that the compound is a ceph-2-em or ceph-3-em compound) and salts thereof, the compounds of formula (I) being associated with an anion when X represents a pyridinium, 3-carbamoylpyridinium group or a 4-carbamoylpyridinium group and R' is other than COO ⊖ ) are disclosed.

    Processes for their preparation and pharmaceutical compositions containing them are also disclosed.