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公开(公告)号：EP2041139B1
公开(公告)日：2011-11-09
申请号：EP07755937.5
申请日：2007-04-24
发明人： FOLKES, Adrian , SHUTTLEWORTH, Stephen , CHUCKOWREE, Irina , OXENFORD, Sally , WAN, Nan Chi , CASTANEDO, Georgette , GUNZNER, Janet , HEFFRON, Tim , MATHIEU, Simon , OLIVERO, Alan , SUTHERLIN, Daniel, P. , ZHU, Bing-Yan , GOLDSMITH, Richard
IPC分类号： C07D491/04
CPC分类号： A61K31/5377 , A61K31/551 , A61K45/06 , C07D491/04 , C07D491/048 , C07D495/04
摘要： Compounds of Formulae la and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula la and Ib for in vitro , in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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2.发明公开PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权磷酸三磷酸激酶HEMMENDE VERBINDUNGEN UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
公开(公告)号：EP2046799A1
公开(公告)日：2009-04-15
申请号：EP07776052.8
申请日：2007-04-24
发明人： CASTANEDO, Georgette , GOLDSMITH, Richard , GUNZNER, Janet , HEFFRON, Tim , MALESKY, Kimberly , MATHIEU, Simon , OLIVERO, Alan , SUTHERLIN, Daniel, P. , TSUI, Vickie , WANG, Shumei , WEISMANN, Christian , ZHU, Bing-Yan , DOTSON, Jennafer , FOLKES, Adrian , SHUTTLEWORTH, Stephen , OXENFORD, Sally , HANCOX, Tim , BAYLISS, Tracy
IPC分类号： C07D491/04 , C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D491/04 , C07D495/04
摘要： Compounds of Formulas (Ia) and (Ib), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula (Ia) and (Ib) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了使用式Ia和Ib的化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：EP2041139A2
公开(公告)日：2009-04-01
申请号：EP07755937.5
申请日：2007-04-24
发明人： FOLKES, Adrian , SHUTTLEWORTH, Stephen , CHUCKOWREE, Irina , OXENFORD, Sally , WAN, Nan Chi , CASTANEDO, Georgette , GUNZNER, Janet , HEFFRON, Tim , MATHIEU, Simon , OLIVERO, Alan , SUTHERLIN, Daniel, P. , ZHU, Bing-Yan , GOLDSMITH, Richard
IPC分类号： C07D491/04
CPC分类号： A61K31/5377 , A61K31/551 , A61K45/06 , C07D491/04 , C07D491/048 , C07D495/04
摘要： Compounds of Formulae la and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula la and Ib for in vitro , in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib化合物及其立体异构体，几何异构体，互变异构体，溶剂化物，代谢物和药学上可接受的盐可用于抑制包括PI3K在内的脂质激酶，以及用于治疗诸如由脂质激酶介导的癌症等疾病。 公开了使用式Ia和Ib化合物体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。
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4.发明公开
公开(公告)号：EP2024372A2
公开(公告)日：2009-02-18
申请号：EP07734376.2
申请日：2007-04-24
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： A61K31/5355 , C07D495/04
摘要： A thienopyrimidine of formula (I) and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110α subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
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公开(公告)号：EP2024372B1
公开(公告)日：2010-06-23
申请号：EP07734376.2
申请日：2007-04-24
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： A61K31/5355 , C07D495/04
摘要： A thienopyrimidine of formula (I) and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110α subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
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6.发明授权PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权磷酸肌醇3-激酶抑制剂化合物和含有它们的药物组合物
公开(公告)号：EP2046799B1
公开(公告)日：2017-07-19
申请号：EP07776052.8
申请日：2007-04-24
发明人： CASTANEDO, Georgette , GOLDSMITH, Richard , GUNZNER, Janet , HEFFRON, Tim , MALESKY, Kimberly , MATHIEU, Simon , OLIVERO, Alan , SUTHERLIN, Daniel, P. , TSUI, Vickie , WANG, Shumei , WEISMANN, Christian , ZHU, Bing-Yan , DOTSON, Jennafer , FOLKES, Adrian , SHUTTLEWORTH, Stephen , OXENFORD, Sally , HANCOX, Tim , BAYLISS, Tracy
IPC分类号： C07D491/04 , C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D491/04 , C07D495/04
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