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    MODIFIED LOW MOLECULAR WEIGHT HEPARIN THAT INHIBITS CLOT ASSOCIATED COAGULATION FACTORS
    1.
    发明公开
    MODIFIED LOW MOLECULAR WEIGHT HEPARIN THAT INHIBITS CLOT ASSOCIATED COAGULATION FACTORS 失效
    改性，低分子量肝素，凝血块相关凝血因子防止

    公开(公告)号：EP0986581A1

    公开(公告)日：2000-03-22

    申请号：EP98925356.2

    申请日：1998-06-05

    申请人： HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC.

    发明人： WEITZ, Jeffrey ,  HIRSH, Jack

    IPC分类号： C08B37/10 ,  A61K31/725

    CPC分类号： C08B37/0078 ,  A61K31/727 ,  Y10S514/921

    摘要： The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, inter alia, is capable of (1) inactivating fluid-phase thrombin and thrombin which is bound either to fibrin in a clot or to some other surface by catalyzing antithrombin; and (2) inhibiting thrombin generation by catalyzing factor Xa inactivation by antithrombin III (ATIII). The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.