公开(公告)号：EP1899356A1

公开(公告)日：2008-03-19

申请号：EP05760572.7

申请日：2005-06-15

申请人： Hetero Drugs Limited

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura, Hetero Drugs Limited (R&D) ,  RAJI REDDY, Rapolu, Hetero Drugs Limited (R&D) ,  MURALIDHARA REDDY, Dasari, Hetero Drugs Ltd. R&D ,  MURALI, Nagabelli, HETERO DRUGS LIMITED

IPC分类号： C07D501/22

CPC分类号： C07D501/00

摘要： The present invention provides an improved process for the preparation of high assayed cefdinir. Thus, crude cefdinir is added to water at 25 - 30°C and then 18% hydrochloric acid is slowly added to form a clear solution. The solution is cooled to -5°C and stirred for 5 minutes at -5°C to +5°C. Then temperature of the mass is raised to 35 - 38°C, stirred for 15 minutes at the same temperature. To the reaction mass eno carbon is added at 35 - 38°C and stirred for 30 minutes at 35 - 38°C. Then the contents are filtered on hiflo bed and washed with water. The filtrate is then cooled to 25°C, the pH is slowly adjusted to 2.6 with saturated sodium bicarbonate solution and stirred for 60 minutes at 25 - 30°C. Filtered the solid, washed with water and dried at 40°C under vacuum to give high assayed cefdinir.