公开(公告)号：EP3611257A1

公开(公告)日：2020-02-19

申请号：EP19200815.9

申请日：2012-08-29

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  CNRS (Centre National de la Recherche Scientifique) ,  UNIVERSITE DE STRASBOURG ,  Association Française contre les Myopathies

发明人： Pourquie, Olivier ,  Chal, Jérôme

IPC分类号： C12N5/0775

摘要： The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.

公开(公告)号：EP2565264A1

公开(公告)日：2013-03-06

申请号：EP11306080.0

申请日：2011-08-29

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Centre National de la Recherche Scientifique - CNRS ,  Université de Strasbourg ,  Association Française contre les Myopathies

发明人： Pourquie, Olivier ,  Chal, Jérôme

IPC分类号： C12N5/0775

CPC分类号： C12N5/0662 ,  C12N2500/62 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/02

摘要： The present invention relates to an ex vivo method for preparing a population of induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signalling pathway.

摘要翻译： 本发明涉及一种用于制备诱导的旁轴中胚层祖细胞（iPAM）细胞群体的离体方法，所述方法包括在包含有效量的Wnt信号传导途径的活化剂的适当培养基中培养多能细胞的步骤。