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1.发明公开1-[(4-HYDROXYPRIDIN-4-YL) METHYL]PYRIDINE-2(1H)-ONE DERIVATIVES, PREPARATION METHODS AND USES THEREOF 审中-公开1 - [（4- HYDROXYPRIDIN -4-基）甲基]吡啶-2（1H） - 酮衍生物，用于生产及其用途
公开(公告)号：EP2570410A4
公开(公告)日：2014-01-08
申请号：EP11780040
申请日：2011-04-08
发明人： LI YUNFENG , YANG RIFANG , ZHANG YOUZHI , LI YONGZHEN , JIN ZENGLING , LI PENG , YUAN LI , YUN LIUHONG , ZHAO NAN , ZHANG CHENG , XU XIAODAN , ZHAO RUSHENG , CHEN HONGXIA , XUE RUI , QIN JUANJUAN , WANG ZHENZHEN , YAO JIAZHI
IPC分类号： C07D401/06 , A61K31/4545 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： C07D401/06
摘要： Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2( 1H )-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
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公开(公告)号：EP2305669A4
公开(公告)日：2012-01-04
申请号：EP09768711
申请日：2009-06-23
发明人： ZHONG BOHUA , ZHANG YOUZHI , ZHANG YANPING , XUE RUI , HE XINHUA , LI YUNFENG , CHEN HONGXIA , ZHAO NAN , LI MEIYING
IPC分类号： C07D407/12 , A61K31/36 , A61K31/381 , A61P25/24 , C07D407/14 , C07D409/12 , C07D409/14
CPC分类号： C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14
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