专利检索 ap:("INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" OR "CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Etablissement Public") AND inv:"AGROFOGLIO, Luigi" 第 1 页

1.

发明公开
URIDINE DERIVATIVES AS ANTIVIRAL DRUGS AGAINST A FLAVIVIRIDAE, ESPECIALLY HCV 审中-公开
标题翻译：尿苷衍生物作为针对黄病毒科病毒的抗病毒剂; 特别是HCV

公开(公告)号：EP1827457A1

公开(公告)日：2007-09-05

申请号：EP05824567.1

申请日：2005-12-22

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Etablissement Public

发明人： AUCAGNE, Vincent , ESCURET, Vanessa , ZOULIM, Fabien , DURANTEL, David , TREPO, Christian , AGROFOGLIO, Luigi , JOUBERT, Nicolas , AMBLARD, Franck

IPC分类号： A61K31/70 , A61P31/12

CPC分类号： A61K31/70

摘要： The invention relates to the use of an uridine derivative of formula (I) : wherein - R1 represents monohalogenated alkynyl or dihalogenated alkenyl; - R2 is chosen from among hydrogen, hydroxyl, O-alkyl, O-CO alkyl and halogen; - R3 is chosen from among hydrogen, hydroxyl, O-alkyl, O-CO alkyl, halogen, SH, S-alkyl and N3; and - R4 is chosen from among hydroxyl, O-alkyl, O-CO alkyl, O-phosphate, O-diphosphate, O-triphosphate and O phosphonate, as well as its possible tautomers, its possible pharmaceutically acceptable addition salts with an acid or a base, and its N-oxide forms, for the preparation of a drug having antiviral activity against a Flaviviridae.